protein

Recombinant Human Dopa Decarboxylase

MBS143550

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Dopa Decarboxylase

Dopa Decarboxylase

Dopa Decarboxylase Human; Dopa Decarboxylase Human Recombinant; DDC; AADC; Aromatic-L-amino-acid decarboxylase; DOPA decarboxylase; Dopa Decarboxylase

aromatic-L-amino-acid decarboxylase isoform 1; Aromatic-L-amino-acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); DOPA decarboxylase; DDC

DDC; DDC; AADC; AADC; AADC; DDC

DDC_HUMAN

E Coli

480

MGSSHHHHHH SSGLVPRGSH TRSMNASEFR RRGKEMVDYV ANYMEGIEGR QVYPDVEPGY LRPLIPAAAP QEPDTFEDII NDVEKIIMPG VTHWHSPYFF AYFPTASSYP AMLADMLCGA IGCIGFSWAA SPACTELETV MMDWLGKMLE LPKAFLNEKA GEGGGVIQGS ASEATLVALL AARTKVIHRL QAASPELTQA AIMEKLVAYS SDQAHSSVER AGLIGGVKLK AIPSDGNFAM RASALQEALE RDKAAGLIPF FMVATLGTTT CCSFDNLLEV GPICNKEDIW LHVDAAYAGS AFICPEFRHL LNGVEFADSF NFNPHKWLLV NFDCSAMWVK KRTDLTGAFR LDPTYLKHSH QDSGLITDYR HWQIPLGRRF RSLKMWFVFR MYGVKGLQAY IRKHVQLSHE FESLVRQDPR FEICVEVILG LVCFRLKGSN KVNEALLQRI NSAKKIHLVP CHLRDKFVLR FAICSRTVES AHVQRAWEHI KELAADVLRA ERE.

Greater than 95.0% as determined by SDS-PAGE.

The Dopa decarboxylase protein solution contains 20mM Tris-HCl, pH-8, 2mM DTT and 10% glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

ENZYMES; Enzymes; Decarboxylase

Description: Dopa decarboxylase human recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 503 amino acids (1-480 a.a.) and having a molecular mass of 56.4 kDa. The Dopa decarboxylase is fused to 23 amino acid His Tag at N-terminus and purified by conventional chromatpgraphy. Introduction: Dopa decarboxylase is a homodimeric, pyridoxal phosphate dependent enzyme. Dopa decarboxylase is involved in 2 metabolic pathways, synthesizing 2 significant neurotransmitters: dopamine and serotonin which both take part in numerous clinical disorders, including Parkinson's disease. Dopa decarboxylase is located in different areas of the brain and is mostly found in basal ganglia. Dopa decarboxylase catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in Dopa decarboxylase leads to aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that causes combined serotonin and catecholamine deficiency.

4503281

NP_000781.1

NM_000790.3

P20711

44,239 Da

Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Amine-derived Hormones Pathway 160983!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!Biogenic Amine Synthesis Pathway 198793!!Catecholamine Biosynthesis Pathway 160984!!Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway 413357!!Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway 468235!!Cocaine Addiction Pathway 546258

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]

0.02 mg

205 USD