Recombinant Human Pregnancy-Associated Plasma Protein-1 | MyBioSource MBS143544 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Pregnancy-Associated Plasma Protein-1

catalog :

MBS143544

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143544

products type :

Recombinant Protein

products full name :

Recombinant Human Pregnancy-Associated Plasma Protein-1

products short name :

Pregnancy-Associated Plasma Protein-1

products name syn :

PAPP A Human; Pregnancy-Associated Plasma Protein-1 Human Recombinant; Pappalysin-1; Pregnancy-associated plasma protein A; PAPP-A; Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPPA; PAPA; DIPLA1; PAPPA1; ASBABP2

other names :

pappalysin-1 preproprotein; Pappalysin-1; pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; pregnacy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1; Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPP-A

products gene name :

PAPP-A

other gene names :

PAPPA; PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase; IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A

uniprot entry name :

PAPP1_HUMAN

host :

E Coli

sequence length :

1627

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

PAPP-A protein is supplied in 1x PBS and 50% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.

products categories :

ENZYMES; Enzymes

products description :

Description: PAPP-A Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 191 amino acids fragment (81-271) corresponding to the PAPP-A œJelly-Roll domain fragment, having a total molecular mass of 30kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The PAPP-A is purified by proprietary chromatographic techniques. Introduction: PAPPA is a large zinc binding protein, which acts as a metalloprotease and specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. PAPP-A can also act as a regulator of IGF bioactivity in a number of biological systems, including the human ovary and cardiovascular systems. It was shown that PAPP A levels are elevated in patients with unstable angina or acute myocardial infarction. Furthermore, PAPPA is believed to be involved in local proliferative processes such as wound healing and bone remodeling. Moreover, PAPP-A is produced in high concentrations during pregnancy and is released into the maternal circulation. In placenta, PAPP A is expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels of PAPPA are found in an array of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. PAPP-A is present in serum and placenta during pregnancy; with levels increasing throughout pregnancy. Low levels of PAPP A are associated with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth.PAPPA levels may be a potentially highly specific marker for heart disease.PAPP-A proteolytic activity is inhibited by targeting substrate exosite binding.

ncbi gi num :

38045915

ncbi acc num :

NP_002572.2

ncbi gb acc num :

NM_002581.3

uniprot acc num :

Q13219

ncbi mol weight :

180,973 Da

ncbi pathways :

Metabolism Of Proteins Pathway (106230); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

ncbi summary :

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

uniprot summary :

PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. Protein type: Secreted; Protease; EC 3.4.24.79; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q33.2. Cellular Component: membrane; extracellular region. Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity. Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage