Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform | MyBioSource MBS143543 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform

catalog :

MBS143543

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143543

products type :

Recombinant Protein

products full name :

Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform

products short name :

A Disintegrin and Metalloproteinase Domain 12 S Isoform

products name syn :

ADAM12 Human; A Disintegrin and Metalloproteinase Domain 12 S-Isoform Human Recombinant; Meltrin alpha; MCMP; MLTN; MLTNA; MCMPMltna; ADAM metallopeptidase domain 12; ADAM 12; ADAM12

other names :

disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein; Disintegrin and metalloproteinase domain-containing protein 12; disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane; ADAM metallopeptidase domain 12; Meltrin-alpha

products gene name :

ADAM12

other gene names :

ADAM12; ADAM12; MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1; MLTN; ADAM 12

uniprot entry name :

ADA12_HUMAN

host :

E Coli

sequence length :

737

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The ADAM12 solution contains 20mM Tris-HCl and 50% Glycerol. Sterile Filtered colorless solution.

concentration :

0.126 mg/ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; A Disintegrin and Metalloproteinase Domain

products description :

Description: ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa. Introduction: ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis. ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).

ncbi gi num :

572882491

ncbi acc num :

NP_001275903.1

ncbi gb acc num :

NM_001288974.1

uniprot acc num :

O43184

ncbi mol weight :

80,263 Da

ncbi pathways :

Disease Pathway (530764); Notch Signaling Pathway (169345); Signal Transduction Pathway (477114); Signaling By EGFR Pathway (106337); Signaling By EGFR In Cancer Pathway (530768); Signaling By EGFRvIII In Cancer Pathway (1127577); Signaling By Ligand-Responsive EGFR Variants In Cancer Pathway (1127576); Signaling By Overexpressed Wild-Type EGFR In Cancer Pathway (1127579); Syndecan-4-mediated Signaling Events Pathway (138064)

ncbi summary :

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

uniprot summary :

ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.4.24.-; Protease. Chromosomal Location of Human Ortholog: 10q26. Cellular Component: nucleoplasm; mitochondrion; plasma membrane; integral to membrane; extracellular region. Molecular Function: protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; SH3 domain binding. Biological Process: epidermal growth factor receptor signaling pathway; cell adhesion; proteolysis; myoblast fusion

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage