protein

Recombinant Human Phenylethanolamine-N-Methyltransferase

MBS143536

1 mg

2220 USD

Recombinant Protein

Recombinant Human Phenylethanolamine-N-Methyltransferase

Phenylethanolamine-N-Methyltransferase

PNMT Human; Phenylethanolamine-N-Methyltransferase Human Recombinant; PENT; PNMTase; Noradrenaline-N-methyltransferase; Phenylethanolamine N-methyltransferase; PNMT; MGC34570

phenylethanolamine N-methyltransferase; Phenylethanolamine N-methyltransferase; phenylethanolamine N-methyltransferase; noradrenaline N-methyltransferase; phenylethanolamine N-methylase; phenylethanolamine N-methyltransferase; Noradrenaline N-methyltransferase

PNMT

PNMT; PNMT; PENT; PNMTase; PENT; PNMTase

PNMT_HUMAN

E Coli

282

MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL.

Greater than 95.0% as determined by SDS-PAGE.

The PNMT protein solution contains 20mM Tris-HCl, pH-8 & 10% Glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

ENZYMES; Enzymes; Transferase

Description: Recombinant Human PNMT produced in E Coli is a single, non-glycosylated polypeptide chain containing 282 amino acids (1-282 a.a.) and having a molecular mass of 30.8 kDa.PNMT is purified by conventional chromatographic techniques. Introduction: PNMT is an enzyme located in the adrenal medulla and it catalyzes the final step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). PNMT has beta-carboline 2N-methyltransferase activity. PNMT takes part in regulating epinephrine production. Glucocorticoid receptors form multimers of PNMT independent of the DNA binding domain. PNMT expression is regulated late in mouse gestation by AP2-alpha and glucocorticoids.

4505921

NP_002677.1

NM_002686.4

P11086

30,855 Da

Amine-derived Hormones Pathway 160983!!Biogenic Amine Synthesis Pathway 198793!!Catecholamine Biosynthesis Pathway 160984!!Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway 413357!!Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway 468235!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!Tyrosine Metabolism Pathway 82959!!Tyrosine Metabolism Pathway 325

The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

1 mg

2220 USD