protein

Recombinant Human WW Domain Containing Oxidoreductase

MBS143535

0.01 mg

205 USD

Recombinant Protein

Recombinant Human WW Domain Containing Oxidoreductase

WW Domain Containing Oxidoreductase

WWOX Human; WW Domain Containing Oxidoreductase Human Recombinant; FOR; WOX1; FRA16D; HHCMA56; PRO0128; SDR41C1; D16S432E; WWOX; WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase

WW domain-containing oxidoreductase isoform 4; WW domain-containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; fragile site FRA16D oxidoreductase; short chain dehydrogenase/reductase family 41C, member 1; WW domain containing oxidoreductase; Fragile site FRA16D oxidoreductase

WWOX

WWOX; WWOX; FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E; FOR; WOX1

WWOX_HUMAN

E Coli

301

MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG.

Greater than 85.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The WWOX solution (1mg/ml) contains 20mM Tris pH-8, & 10% glycerol. Sterile Filtered colorless solution.

WWOX although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

ENZYMES; Enzymes; Reductase

Description: WWOX Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 254 amino acids (1-234 a.a.) and having a molecular mass of 28.3 kDa.The WWOX is purified by proprietary chromatographic techniques. Introduction: WWOX is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and involved in the regulation of a broad range of cellular functions such as protein degradation, transcription, and RNA splicing. WWOX functions synergistically with TP53/p53 to control genotoxic stress-induced cell death. WWOX takes part in tumor necrosis factor (TNF)-mediated cell death. Loss of WWOX expression is associated with pancreatobiliary cancers. Reduced expression levels of WWOX protein is associated with the pathogenesis of basal-like differentiation in breast cancer. Loss of WWOX expression is associated with extrahepatic cholangiocarcinoma. WWOX gene alteration is an early genetic alteration contributes to oral carcinogenesis. WWOX induces apoptosis and inhibits human hepatocellular carcinoma cell growth through a mechanism enhanced by JNK inhibition.

635172870

NP_001278926.1

NM_001291997.1

Q9NZC7

23,868 Da

ErbB4 Signaling Events Pathway 137991!!Nuclear Signaling By ERBB4 Pathway 530744!!Signal Transduction Pathway 477114!!Signaling By ERBB4 Pathway 530741

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

0.01 mg

205 USD