protein

Recombinant Human Neurotrophin-4

MBS143528

0.01 mg

205 USD

Recombinant Protein

Recombinant Human Neurotrophin-4

Neurotrophin-4

NT 4 Human; Neurotrophin-4 Human Recombinant; NT4; NT5; NTF5; NT-4/5; NTF4; Neurotrophin-4; Neutrophic factor 4; Neurotrophin-5; NT-5

neurotrophin-4 preproprotein; Neurotrophin-4; neurotrophin-4; neurotrophic factor 4; neurotrophic factor 5; neurotrophin 5 (neurotrophin 4/5); neurotrophin-5; neutrophic factor 4; neurotrophin 4; Neurotrophin-5; NT-5; Neutrophic factor 4

NT 4

NTF4; NTF4; NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5; NTF5; NT-4; NT-5

NTF4_HUMAN

E Coli

210

GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA.

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from a concentrated (1mg/ml) solution in water containing 20mM phosphate buffer pH-7.4 and 150mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized NT-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution NT-4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized NT-4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.

CYTOKINES AND GROWTH FACTORS; Neurotrophins

Description: Neurotrophin-4 Human Recombinant produced in E Coli is a noncovalently linked homodimer, non-glycosylated polypeptide chain containing 2 x 130 amino acids (81-210 amino acids) and having a total molecular mass of 28 kDa. The NT-4 is purified by proprietary chromatographic techniques. Introduction: NT-4 is part of the family of neurotrophic factors, neurotrophins, that are in charge for the survival and differentiation of mammalian neurons. NT-4 expression is dominant and less influenced by environmental signals. NT-4 deficient mice shows slight cellular deficits and develop normally to adulthood. NT-4 is a target-derived survival factor for peripheral sensory sympathetic neurons.NT-4 is involved in the proliferation and differentiation of periodontal ligament cells.

5453808

NP_006170.1

NM_006179.4

P34130

22,427 Da

MAPK Signaling Pathway 198779!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!Neurotrophic Factor-mediated Trk Receptor Signaling Pathway 137977!!Neurotrophin Signaling Pathway 101143!!Neurotrophin Signaling Pathway 100064!!P75(NTR)-mediated Signaling Pathway 138019

This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

0.01 mg

205 USD