protein

Recombinant Human Aldo-Keto Reductase Family 7 Member A2

MBS143510

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Aldo-Keto Reductase Family 7 Member A2

Aldo-Keto Reductase Family 7 Member A2

AKR7A2 Human; Aldo-Keto Reductase Family 7 Member A2 Human Recombinant; Aflatoxin B1 aldehyde reductase member 2; AFAR; AFAR1; AFB1-AR1; AKR7; Succinic semialdehyde reductase; SSA reductase; AFB1 aldehyde reductase 1; Aldoketoreductase 7; AKR7A2

aflatoxin B1 aldehyde reductase member 2; Aflatoxin B1 aldehyde reductase member 2; aflatoxin B1 aldehyde reductase member 2; AFB1 aldehyde reductase 1; AFB1-AR 1; HEL-S-166mP; SSA reductase; aflatoxin beta1 aldehyde reductase; aldoketoreductase 7; epididymis secretory sperm binding protein Li 166mP; succinic semialdehyde reductase; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase

AKR7A2

AKR7A2; AKR7A2; AFAR; AKR7; AFAR1; AFB1-AR1; AFAR; AFAR1; AKR7; AFB1-AR 1; SSA reductase

ARK72_HUMAN

E Coli

359

Greater than 90.0% as determined by SDS-PAGE.

The AKR7A2 solution contains 20mM Tris-HCl pH-8, 1mM DTT and 20% glycerol. Sterile Filtered clear colorless solution.

Biological Activity: Specific activity: approximately 0.25-0.3 units/mg.Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25C. Specific activity was expressed as units/mg protein.

ENZYMES; Enzymes; Reductase

Description: AKR7A2 Human Recombinant fused to a 39 amino acid His Tag at N-terminal produced in E Coli is a single, non-glycosylated, polypeptide chain containing 398 amino acids (1-359 a.a) and having a molecular mass of 44 kDa. The AKR7A2 is purified by proprietary chromatographic techniques. Introduction: AKR7A2 participates in the detoxification of aldehydes and ketones. AKR7A2 catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. AKR7A2 is involved in producing the neuromodulator gamma-hydroxybutyrate (GHB). AKR7A2 has extensive substrate specificity. AKR7A2 shows NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2 reduces 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). AKR7A2 reduces the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. AKR7A2 takes part in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

41327764

NP_003680.2

NM_003689.3

O43488

39,589 Da

Aflatoxin B1 Metabolism Pathway 198808!!Aflatoxin Activation And Detoxification Pathway 1127511!!Biological Oxidations Pathway 105698!!Defective ACY1 Causes Encephalopathy Pathway 1127638!!Disease Pathway 530764!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Metabolism Pathway 477135!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 83031!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 425!!Metapathway Biotransformation 198837

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]

0.02 mg

205 USD