catalog number :
MBS143505
products type :
Recombinant Protein
products full name :
Recombinant Human Vesicle-Associated Membrane Protein 4
products short name :
Vesicle-Associated Membrane Protein 4
products name syn :
VAMP4 Human; Vesicle-associated membrane protein 4 Human Recombinant; Vesicle-associated membrane protein 4; VAMP-4; VAMP4; VAMP24
other names :
vesicle-associated membrane protein 4 isoform 2; Vesicle-associated membrane protein 4; vesicle-associated membrane protein 4; vesicle-associated membrane protein 4
products gene name :
VAMP4
other gene names :
VAMP4; VAMP4; VAMP-4; VAMP24; VAMP-4
uniprot entry name :
VAMP4_HUMAN
sequence :
MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKLEHHH HHH.
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The VAMP4 protein solution contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, and 20% glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Synaptobrevin
products description :
Description: VAMP4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 123 amino acids (1-115 a.a.) and having a molecular mass of 14.5kDa.VAMP4 is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques. Introduction: VAMP4 belongs to the synaptobrevin family who are involved in docking and/or fusion of vesicles with cell membrane. VAMP4 is enriched in the trans-Golgi network and may be a factor in the trans-Golgi network-to-endosome transport. VAMP4 is involved in the pathway which functions to eliminate an inhibitor (most likely synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. Synaptobrevins, syntaxins, and SNAP25 are the chief components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.
ncbi acc num :
NP_001172056.1
ncbi gb acc num :
NM_001185127.1
ncbi mol weight :
16,241 Da
ncbi pathways :
SNARE Interactions In Vesicular Transport Pathway 83057!!SNARE Interactions In Vesicular Transport Pathway 467
ncbi summary :
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]