catalog number :
MBS143492
products type :
Recombinant Protein
products full name :
Recombinant Human HRAS-Like Suppressor 3 (PLA2G16)
products short name :
HRAS-Like Suppressor 3
products name syn :
HRASLS3 Human; HRAS-Like Suppressor 3 Human Recombinant (PLA2G16); PLA2G16; Phospholipase A2 Group XVI; AdPLA; H-REV107-1; HREV107; HREV107-3; MGC118754; HRAS-like suppressor 3; H-rev 107 protein homolog; Renal carcinoma antigen NY-REN-65; HRASLS3
other names :
HRAS-like suppressor 3; HRAS-like suppressor 3; HRAS-like suppressor 3; Ca-independent phospholipase A1/2; H-rev 107 protein homolog; HRAS-like suppressor 1; adipose-specific PLA2; adipose-specific phospholipase A2; group XVI phospholipase A1/A2; group XVI phospholipase A2; renal carcinoma antigen NY-REN-65; phospholipase A2, group XVI; Adipose-specific phospholipase A2; AdPLA; Group XVI phospholipase A1/A2; H-rev 107 protein homolog; HRAS-like suppressor 1; HREV107-1; HREV107-3; Renal carcinoma antigen NY-REN-65
products gene name :
HRASLS3
other gene names :
PLA2G16; PLA2G16; AdPLA; HRSL3; HRASLS3; HREV107; HREV107-1; HREV107-3; H-REV107-1; HRASLS3; HREV107; HRSL3; AdPLA
uniprot entry name :
HRSL3_HUMAN
sequence :
MRAPIPEPKP GDLIEIFRPF YRHWAIYVGD GYVVHLAPPS EVAGAGAASV MSALTDKAIV KKELLYDVAG SDKYQVNNKH DDKYSPLPCS KIIQRAEELV GQEVLYKLTS ENCEHFVNEL RYGVARSDQV RDV.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
The protein contains 20mM Tris-HCl buffer pH 8. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
products categories :
ENZYMES; Enzymes; Secreted Phospholipase A2
products description :
Description: HRASLS3 Human Recombinant amino produced in E Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-133) having a molecular mass of 14.9 kDa. The HRASLS3 is purified by proprietary chromatographic techniques. Introduction: HRASLS3 is a tumor suppressor that takes part in interferon- dependent cell death. HRASLS3 is part of the class II tumor suppressor gene family and is involved in the regulation of differentiation and survival. HRASLS3 protein is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas.
ncbi acc num :
NP_001121675.1
ncbi gb acc num :
NM_001128203.1
ncbi mol weight :
17,937 Da
ncbi pathways :
Acyl Chain Remodelling Of PC Pathway (645321); Acyl Chain Remodelling Of PE Pathway (645317); Acyl Chain Remodelling Of PI Pathway (645326); Acyl Chain Remodelling Of PS Pathway (645324); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (366); Ether Lipid Metabolism Pathway (82990); Ether Lipid Metabolism Pathway (365); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989)
uniprot summary :
PLA2G16: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. Belongs to the H-rev107 family. Protein type: EC 3.1.1.32; EC 3.1.1.4; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q12.3. Cellular Component: endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane; cytosol. Molecular Function: phospholipase A2 activity; protein binding; phospholipase A1 activity. Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; lipid catabolic process; negative regulation of cell cycle