protein

Human Transforming Growth Factor-Beta 1

MBS143480

0.001 mg

455 USD

Native Protein

Human Transforming Growth Factor-Beta 1

Transforming Growth Factor-Beta 1

TGF b 1 Human; Transforming Growth Factor-beta 1 Human; Transforming growth factor beta-1; TGF-beta-1; CED; DPD1; TGFB; TGF-b 1

transforming growth factor beta-1; Transforming growth factor beta-1; transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1; transforming growth factor, beta 1

TGF b 1

TGFB1; TGFB1; CED; LAP; DPD1; TGFB; TGFbeta; TGFB; TGF-beta-1; LAP

TGFB1_HUMAN

Human Platelets

390

Greater than 98.0% as determined by SDS-PAGE.

TGF-Beta1 protein was lyophilized from a solution containing 30% acetonitrile and 0.1% trifluoroacetic acid. . Sterile Filtered lyophilized powder.

Lyophilized TGF-beta 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TGF-beta 1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.DO NOT RECONSTITE WITH NEUTRAL BUFFERS.DO NOT USE GLASS IMPLEMENTS OR EXTENSIVE MANIPULATIONS.PREVENT FREEZE THAW CYCLES.

Solubility: It is recommended to reconstitute lyophilized TGF-beta 1 in 0.5% BSA in 0.1N acetic acid, which can then be further diluted to the desired aliquot with 30% acetonitrile and 0.1% trifluoroacetic acid. Biological Activity: Stimulates the growth of NRK-1 cells in soft agar at concentrations ranging from 0.1 to 5ng/ml corresponding to a specific activity of 200,000-10,000,000IU/mg. Effective concentration ranges must be experimentally determined. Purified EGF and/or TGF- must be present for observation of the biological activity.

CYTOKINES AND GROWTH FACTORS; Growth Factors; Transforming Growth Factor

Description: Human Transforming Growth Factor-beta 1 purified from Human Platelets having a molecular mass of 25kDa.The TGF-b 1 is purified by proprietary chromatographic techniques. Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGFBetas have been identified in mammals. TGFBeta1, TGFBeta2 and TGFBeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

63025222

NP_000651.3

NM_000660.5

P01137

44,341 Da

ACE Inhibitor Pathway 198763!!ALK1 Signaling Events Pathway 137968!!Adipogenesis Pathway 198832!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cardiac Progenitor Differentiation Pathway 712094!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Chagas Disease (American Trypanosomiasis) Pathway 147809

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]

0.001 mg

455 USD