Rat Epidermal Growth Factor | MyBioSource MBS143476 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Rat Epidermal Growth Factor

catalog :

MBS143476

quantity :

0.002 mg

price :

265 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143476

products type :

Native Protein

products full name :

Rat Epidermal Growth Factor

products short name :

Epidermal Growth Factor

products name syn :

EGF Rat; Epidermal Growth Factor Rat; Urogastrone; URG; EGF

other names :

pro-epidermal growth factor; Pro-epidermal growth factor; pro-epidermal growth factor; epidermal growth factor

products gene name :

rEGF

other gene names :

Egf; Egf; EGF

uniprot entry name :

EGF_RAT

host :

Adult Male Rat Submandibular Glands

sequence length :

1133

purity :

Greater than 99.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein was lyophilized from a concentrated (1mg/ml) solution containing 0.01M sodium acetate buffer. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Epidermal Growth Factor Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution EGF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Epidermal Growth Factor in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Epidermal Growth Factor

products description :

Description: Epidermal Growth Factor Rat purified from submandibular gland is a single, glycosylated, polypeptide chain having a molecular mass of 6.15 kDa.The EGF is purified by proprietary chromatographic techniques. Introduction: Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide.EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.

ncbi gi num :

6978797

ncbi acc num :

NP_036974.1

ncbi gb acc num :

NM_012842.1

uniprot acc num :

P07522

ncbi mol weight :

124,126 Da

ncbi pathways :

Adaptive Immune System Pathway (1121508); Bladder Cancer Pathway (83503); Bladder Cancer Pathway (527); Cardiovascular Signaling Pathway (219769); Choline Metabolism In Cancer Pathway (1060542); Choline Metabolism In Cancer Pathway (1084232); Constitutive PI3K/AKT Signaling In Cancer Pathway (1121891); Constitutive Signaling By EGFRvIII Pathway (1121858); Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway (1121856); Cytokine-cytokine Receptor Interaction Pathway (83443)

ncbi summary :

binds the epidermal growth factor receptor; may play a role in MAP kinase mediated signaling pathways [RGD, Feb 2006]

uniprot summary :

EGF: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ligand, receptor tyrosine kinase; Hormone; Membrane protein, integral. Cellular Component: extracellular space; lysosomal membrane; plasma membrane; integral to membrane; intracellular. Molecular Function: growth factor activity; calcium ion binding; epidermal growth factor receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; activation of MAPKK activity; positive regulation of mitosis; positive regulation of transcription, DNA-dependent; regulation of protein transport; positive regulation of MAP kinase activity; regulation of protein secretion; branching morphogenesis of a tube; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; negative regulation of secretion; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; STAT protein nuclear translocation; positive regulation of DNA binding; positive regulation of granule cell precursor proliferation

size1 :

0.002 mg

price1 :

265 USD

size2 :

0.005 mg

price2 :

365

size3 :

0.01 mg

price3 :

610

more info or order :

MyBioSource product webpage