catalog number :
MBS143456
products type :
Recombinant Protein
products full name :
Recombinant Human Synaptobrevin-3
products short name :
Synaptobrevin-3
products name syn :
VAMP3 Human; Synaptobrevin-3 Human Recombinant; VAMP3; VAMP-3; Cellubrevin; Vesicle-Associated Membrane Protein 3; Synaptobrevin-3; CEB; SYB3
other names :
vesicle-associated membrane protein 3; Vesicle-associated membrane protein 3; vesicle-associated membrane protein 3; VAMP-3; cellubrevin; synaptobrevin-3; vesicle-associated membrane protein 3; Cellubrevin; CEB; Synaptobrevin-3
products gene name :
VAMP3
other gene names :
VAMP3; VAMP3; CEB; SYB3; VAMP-3; CEB
uniprot entry name :
VAMP3_HUMAN
sequence :
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA DALQAGASQF ETSAAKLKRK YWWKNCK.
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The VAMP3 protein solution contains 20mM Tris pH-7.5 and 10% glycerol. Sterile Filtered colorless solution.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Synaptobrevin
products description :
Description: VAMP3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa. Introduction: VAMP3 is present in recycling endosomes and endosome-derived vesicles. VAMP3 has been implicated in recycling of transferrin receptors to the plasma membrane, secretion of alpha-granules in platelets, recycling of T-cell receptors to the immunological synapses, and membrane trafficking during cell migration. VAMP-3 is present in human platelets and necessary for granule secretion. Synaptobrevins are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 high homology to other VAMPs in its broad tissue distribution and subcellular localization is shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
ncbi acc num :
NP_004772.1
ncbi gb acc num :
NM_004781.3
ncbi mol weight :
11,309 Da
ncbi pathways :
Arf6 Trafficking Events Pathway 137954!!Phagosome Pathway 153910!!Phagosome Pathway 153859!!SNARE Interactions In Vesicular Transport Pathway 83057!!SNARE Interactions In Vesicular Transport Pathway 467
ncbi summary :
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]