protein

Recombinant Human Advanced Glycosylation End Product-Specific Receptor

MBS143449

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Advanced Glycosylation End Product-Specific Receptor

[Advanced Glycosylation End Product-Specific Receptor]

[sRAGE Human; Advanced Glycosylation End Product-Specific Receptor Human Recombinant; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; AGER; SRAGE; RAGE; MGC22357]

[advanced glycosylation end product-specific receptor isoform 1; Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; receptor for advanced glycation end-products variant 20; advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products]

[sRAGE]

[AGER; AGER; RAGE; RAGE]

RAGE_HUMAN

E Coli

404

MRGSHHHHHH GMASATPKQG PRMLGAPEEA DANEEGVRRA LDFAVSEYNK GSNDAYHSRA IQVVRARKQL VAGVNYFLDV EMGRTTCTKS QTNLTDCPFH DQPHLMRKAL CSFQIYSVPW KGTHSLTKFSCKNA.

Greater than 95% as determined by SDS-PAGE.

The sterile filtered concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 50mM NaCl pH-7.5. Sterile Filtered White lyophilized (freeze-dried) powder.

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time.

Solubility: Add 0.1M Acetate buffer pH4 to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Advanced Glycosylation End Product-Specific Receptor

Description: sRAGE Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids and having a molecular mass of 15kDa. The Human sRAGE is fused to His tag at N-Terminus.The Human sRAGE is purified by proprietary chromatographic techniques. Introduction: sRAGE is a member of the immunoglobulin superfamily of cell surface molecules. sRAGE is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. sRAGE lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. sRAGE mediates interactions of nonenzymatic glycosylated proteins which accumulate in vascular tissue during aging & at an increasing rate in diabetes. sRAGE is a receptor for amyloid beta peptide.

10835203

NP_001127.1

NM_001136.4

Q15109

41,098 Da

AGE/RAGE Pathway (698754); Activated TLR4 Signalling Pathway (106400); Advanced Glycosylation Endproduct Receptor Signaling Pathway (187092); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (833822); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88 Cascade Initiated On Plasma Membrane Pathway (205107); MyD88 Dependent Cascade Initiated On Endosome Pathway (187081); MyD88-independent Cascade Pathway (106401)

0.002 mg

140 USD

0.01 mg

205

1 mg

5775