protein

Recombinant Human SMAC/DIABLO

MBS143447

0.02 mg

205 USD

Recombinant Protein

Recombinant Human SMAC/DIABLO

SMAC/DIABLO

SMAC/DIABLO Human; SMAC/DIABLO Human Recombinant; Diablo homolog mitochondrial; Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI; DIABLO; SMAC; SMAC3; DIABLO-S; FLJ10537; FLJ25049

diablo homolog, mitochondrial isoform 4; Diablo homolog, mitochondrial; diablo homolog, mitochondrial; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase; diablo, IAP-binding mitochondrial protein; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac

SMAC/DIABLO

DIABLO; DIABLO; SMAC; DFNA64; SMAC; Smac

DBLOH_HUMAN

E Coli

142

MASMTGGQQM GRGSMAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED.

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The Smac/Diablo solution contains 20mM Tris pH-7.5. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: Smac/Diablo Human Recombinant fused to N-terminal T7-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids and having a molecular mass of 22 kDa. Introduction: Smac/Diablo is a proapoptotic protein that increases caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by its binding to the inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. Smac/Diablo is a mitochondrial protein which enters the cytosol when cells go through apoptosis, and it moderates the caspase inhibition of IAPs.Smac/DIABLO expression is associated with the result of renal cell carcinoma.Dimeric form of Smac/DIABLO implies that once expressed in the cell the protein has a little probability of dissociation and, thus, loss of function. Survivin, Smac/DIABLO, & PKC-? play an important part in the inhibition of apoptosis by FGF-2 in human small cell lung cancer cells. Mitochondrial survivin associates with Smac/DIABLO, delaying its release. Decreased expression of Smac protein takes part in ovarian carcinogenesis and chemotherapeutic resistance. Smac/DIABLO plays a role in tumor cells during the pathway of apoptosis induction. SMAC protein is regulated by XIAP and degraded by proteasome. SMAC protein takes part inleukemic cell apoptosis. Smac is released during stress-induced apoptosis in multiple myeloma cells.

508083041

NP_001265231.1

NM_001278302.1

Q9NR28

22,284 Da

Apoptosis Pathway 198797!!Apoptosis Pathway 105648!!Apoptosis Modulation And Signaling Pathway 198822!!Apoptotic Factor-mediated Response Pathway 105669!!Caspase Cascade In Apoptosis Pathway 137974!!Intrinsic Pathway For Apoptosis 105656!!Programmed Cell Death Pathway 1127510!!Release Of Apoptotic Factors From The Mitochondria Pathway 105668!!SMAC Binds To IAPs Pathway 105674!!SMAC-mediated Apoptotic Response Pathway 105673

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

0.02 mg

205 USD