protein

Recombinant Retnoid Acid Receptor Alpha

MBS143444

1 mg

2665 USD

Recombinant Protein

Recombinant Retnoid Acid Receptor Alpha

Retnoid Acid Receptor Alpha

RARA Human; Retinoic Acid Receptor Alpha Human Recombinant; Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1; RAR; NR1B1; RARA

retinoic acid receptor alpha isoform 1; Retinoic acid receptor alpha; retinoic acid receptor alpha; RAR-alpha; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, alpha; Nuclear receptor subfamily 1 group B member 1

RARA

RARA; RARA; RAR; NR1B1; NR1B1; RAR-alpha

RARA_HUMAN

E Coli

462

MGSSHHHHHH SSGLVPRGSH MSEEIVPSPP SPPPLPRIYK PCFVCQDKSSGYHYGVSACE GCKGFFRRSI QKNMVYTCHR DKNCIINKVT RNRCQYCRLQ KCFEVGMSKESVRNDRNKKK KEVPKPE.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein solution contains 20mM Tris pH-7.5, 0.1M NaCl & 5mM b-ME. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: Retinoic-Acid Receptor Alpha Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 127 amino acids and having a molecular mass of 14 kDa. Introduction: Retinoic acid receptor alpha (RAR) belongs to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. There are three isotypes of RAR proteins: alpha, beta, and gamma. The RAR proteins are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. RARA is a receptor for retinoic acid that has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. RARA controls cell function by directly regulating gene expression.Chromosomal aberrations involving RARA cause acute promyelocytic leukemia (APL).

4506419

NP_000955.1

NM_000964.3

P10276

39,700 Da

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adipogenesis Pathway 198832!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!IL-3 Signaling Pathway 198881!!Integrated Pancreatic Cancer Pathway 711360!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Nuclear Receptors In Lipid Metabolism And Toxicity Pathway 198887

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

1 mg

2665 USD