protein

Recombinant Human KISS-1 Metastasis-Suppressor

MBS143432

0.01 mg

205 USD

Recombinant Protein

Recombinant Human KISS-1 Metastasis-Suppressor

KISS-1 Metastasis-Suppressor

KISS1 Human; KISS-1 Metastasis-Suppressor Human Recombinant; Kisspeptin-1; KISS-1; METASTIN; Metastasis-suppressor KiSS-1; KISS1; MGC39258

metastasis-suppressor KiSS-1 preproprotein; Metastasis-suppressor KiSS-1; metastasis-suppressor KiSS-1; kisspeptin-1; malignant melanoma metastasis-suppressor; metastin; prepro-kisspeptin; KiSS-1 metastasis-suppressor; Kisspeptin-1Cleaved into the following 4 chains:MetastinAlternative name(s):Kisspeptin-54

KISS1

KISS1; KISS1; HH13; KiSS-1

KISS1_HUMAN

E Coli

138

MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG.

Greater than 90.0% as determined by SDS-PAGE.

The protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. Sterile Filtered colorless solution.

KISS1 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: KISS1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (20-138) and having a molecular mass of 12.6 Dalton. The KISS1 is purified by proprietary chromatographic techniques. Introduction: KISS1 is a metastasis suppressor protein that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity.KISS1 functions to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. KISS1 is involved in the regulation of cell-matrix adhesion. KISS1 plays a role in cytoskeletal reorganization. A polymorphism in the terminal exon of KISS1 mRNA results in two protein isoforms. Expression of KiSS1 is localized to specific regions of the hypothalamus in numerous species and is regulated by gonadal steroids and across the estrous cycle. KISS1 generates a c-terminally amidated peptide, metastin which functions as the endogenous ligand of the g-protein coupled receptor gpr54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.

116829964

NP_002247.3

NM_002256.3

Q15726

14,705 Da

Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Gastrin-CREB Signalling Pathway Via PKC And MAPK 645295!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Peptide Ligand-binding Receptors Pathway 106358!!Signal Transduction Pathway 477114

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]

0.01 mg

205 USD