protein

Recombinant Human Interferon Stimulated Gene 15

MBS143431

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Interferon Stimulated Gene 15

Interferon Stimulated Gene 15

ISG15 Human; Interferon stimulated gene 15 Human Recombinant; ISG15; G1P2; IFI15; UCRP; Interferon-induced 17 kDa protein precursor; ISG15 Ubiquitin-like modifier

ubiquitin-like protein ISG15; Ubiquitin-like protein ISG15; ubiquitin-like protein ISG15; interferon, alpha-inducible protein (clone IFI-15K); interferon-induced 17-kDa/15-kDa protein; interferon-stimulated protein, 15 kDa; ubiquitin cross-reactive protein; ISG15 ubiquitin-like modifier; Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRP

ISG15

ISG15; ISG15; G1P2; IP17; UCRP; IFI15; IMD38; hUCRP; G1P2; UCRP; IP17; hUCRP

ISG15_HUMAN

E Coli

165

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The ISG15 solution contains 20mM Tris-HCl pH-8, 100mM NaCl and 1mM DTT. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Ubiquitin

Description: ISG15 Human Recombinant fused to N-terminal Calmudulin Tag (151 a.a.) produced in E Coli is a single, non-glycosylated polypeptide chain containing a total of 308 amino acids (157 a.a. without tag) and having a molecular mass of 34 kDa. Introduction: ISG15 ubiquitin-like Modifier is conjugated to the intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the ub conjugation pathway at the level of a specific E2 enzyme. ISG15 protein targets include STAT1, SERPINA 3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MXA, and RIG-1. Deconjugated by USP18/UBP43 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 serves as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 plays a role in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing ifn-gamma secretion by monocytes and macrophages. ISG15 displays antiviral activity during viral infections. ISG15 in response to IFN-TAU secreted by the conceptus, ligates to and regulate proteins involved in the release of prostaglandin F2-alpha and thus prevent lysis of the corpus luteum and maintain the pregnancy.The interferon-stimulated gene having a molecular mass of 15 kDa is an interferon regulated gene that is induced as a primary response to diverse microbial and cell stress stimuli, and encodes the founding member of the ubiquitin-like protein family. ISG15 shares several common properties with other ubiquitin-like molecules, but its activity is strongly regulated by precise signaling pathways that have a role in innate immunity.

4826774

NP_005092.1

NM_005101.3

P05161

17,888 Da

Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!Cytokine Signaling In Immune System Pathway 366171!!ISG15 Antiviral Mechanism Pathway 530761!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Interferon Signaling Pathway 187103!!Interferon Alpha/beta Signaling Pathway 187104!!Negative Regulators Of RIG-I/MDA5 Signaling Pathway 187102!!RIG-I-like Receptor Signaling Pathway 117292!!RIG-I-like Receptor Signaling Pathway 116128

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

0.01 mg

140 USD