protein

Recombinant Human Ferritin Heavy Chain

MBS143428

1 mg

3465 USD

Recombinant Protein

Recombinant Human Ferritin Heavy Chain

Ferritin Heavy Chain

FTH1 Human; Ferritin Human Recombinant, Heavy Chain; Ferritin heavy chain; Cell proliferation-inducing gene 15 protein; FTH1; FHC; FTH; PLIF; FTHL6; PIG15; MGC104426; Ferritin Heavy

ferritin heavy chain; Ferritin heavy chain; ferritin heavy chain; apoferritin; cell proliferation-inducing gene 15 protein; ferritin H subunit; placenta immunoregulatory factor; proliferation-inducing protein 15; ferritin, heavy polypeptide 1; Cell proliferation-inducing gene 15 proteinFerritin heavy chain, N-terminally processed

FTH1; FTH1; FHC; FTH; HFE5; PLIF; FTHL6; PIG15; FTH; FTHL6; Ferritin H subunit

FRIH_HUMAN

E Coli

183

MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES.

Greater than 95.0% as determined by SDS-PAGE.

The FTH1 protein solution contains 20mM Tris-HCl pH-7.5, 1mM DTT and 10% glycerol. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Ferritin

Description: FTH1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 183 amino acids and having a molecular mass of 21 kDa. Introduction: Ferritin is a fairly large, iron-storage heteropolymeric protein composed of 2 subunit types, light Ferritin & heavy Ferritin polypeptides, which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin is composed of 24 self-assembled polypeptide subunits of the heavy and light ferritin chains and is characterized by the capacity to remove Fe (II) from solution in the presence of oxygen. Ferritin light polypeptide protein is the main intracellular iron storage protein in prokaryotes and eukaryotes. Variation in ferritin subunit composition influence the rates of iron uptake and release in various tissues. A key function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyper ferrit anemia-cataract syndrome. Ferritin stores iron in a soluble, nontoxic, readily accessible form. Ferritin is needed for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after it has been oxidized.

56682959

NP_002023.2

NM_002032.2

P02794

21,226 Da

Binding And Uptake Of Ligands By Scavenger Receptors Pathway 771599!!Clathrin Derived Vesicle Budding Pathway 119545!!Golgi Associated Vesicle Biogenesis Pathway 119546!!Iron Metabolism In Placenta Pathway 672461!!Iron Uptake And Transport Pathway 187191!!Membrane Trafficking Pathway 106160!!Mineral Absorption Pathway 212237!!Mineral Absorption Pathway 212220!!Scavenging By Class A Receptors Pathway 833814!!Transmembrane Transport Of Small Molecules Pathway 106572

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

1 mg

3465 USD