protein

Recombinant Human Ferritin Light Chain

MBS143427

1 mg

3465 USD

Recombinant Protein

Recombinant Human Ferritin Light Chain

Ferritin Light Chain

Ferritin Human, FTL; Ferritin Human Recombinant, Light Chain; Ferritin; FTL; MGC71996; Ferritin light chain; Ferritin Light

ferritin light chain; Ferritin light chain; ferritin light chain; ferritin L subunit; ferritin L-chain; ferritin light polypeptide-like 3; ferritin, light polypeptide

FTL; FTL; LFTD; NBIA3; Ferritin L subunit

FRIL_HUMAN

E Coli

175

MSSQIRQNYS TDVEAAVNSL VNLYLQASYT YLSLGFYFDR DDVALEGVSH FFRELAEEKR EGYERLLKMQ NQRGGRALFQ DIKKPAEDEW GKTPDAMKAA MALEKKLNQA LLDLHALGSA RTDPHLCDFL ETHFLDEEVK LIKKMGDHLT NLHRLGGPEA GLGEYLFERL TLKHD.

Greater than 90.0% as determined by SDS-PAGE.

The protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5. Sterile Filtered solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Ferritin

Description: Ferritin Human Recombinant Light Chain produced in E Coli is a single, non-glycosylated polypeptide chain containing 175 amino acids and having a molecular mass of 20 kDa. Introduction: Ferritin is a fairly large, iron-storage heteropolymeric protein composed of 2 subunit types, light Ferritin & heavy Ferritin polypeptides, which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin is composed of 24 self-assembled polypeptide subunits of the heavy and light ferritin chains and is characterized by the capacity to remove Fe from solution in the presence of oxygen. Ferritin light polypeptide protein is the main intracellular iron storage protein in prokaryotes and eukaryotes. Variation in ferritin subunit composition influence the rates of iron uptake and release in various tissues. A key function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyper ferrit anemia-cataract syndrome. Ferritin stores iron in a soluble, nontoxic, readily accessible form. Ferritin is needed for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after it has been oxidized.

20149498

NP_000137.2

NM_000146.3

P02792

20,020 Da

Binding And Uptake Of Ligands By Scavenger Receptors Pathway 771599!!Clathrin Derived Vesicle Budding Pathway 119545!!Golgi Associated Vesicle Biogenesis Pathway 119546!!Integrated Pancreatic Cancer Pathway 711360!!Iron Uptake And Transport Pathway 187191!!Membrane Trafficking Pathway 106160!!Mineral Absorption Pathway 212237!!Mineral Absorption Pathway 212220!!Scavenging By Class A Receptors Pathway 833814!!Transmembrane Transport Of Small Molecules Pathway 106572

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

1 mg

3465 USD