protein

Recombinant Human DNA Damage Inducible Transcript 3

MBS143423

0.02 mg

205 USD

Recombinant Protein

Recombinant Human DNA Damage Inducible Transcript 3

DNA Damage Inducible Transcript 3

DDIT3 Human; DNA Damage Inducible Transcript 3 Human Recombinant; DNA damage-inducible transcript 3; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153; C/EBP-homologous protein; CHOP; DDIT3; GADD153; CEBPZ; CHOP10; MGC4154

DNA damage-inducible transcript 3 protein isoform 1; DNA damage-inducible transcript 3 protein; DNA damage-inducible transcript 3 protein; C/EBP zeta; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP-homologous protein 10; growth arrest and DNA damage-inducible protein GADD153; DNA-damage-inducible transcript 3; C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153

DDIT3

DDIT3; DDIT3; CHOP; CEBPZ; CHOP10; CHOP-10; GADD153; CHOP; CHOP10; GADD153; DDIT-3; CHOP; CHOP-10

DDIT3_HUMAN

E Coli

192

Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The DDIT3 protein solution (1mg/ml) contains 20mM Tris-HCl pH-8 and 20% glycerol. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; DNA-Damage Protein

Description: DDIT3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids and having a molecular mass of 21 kDa. The DDIT3 protein is fused to a 20 amino acids His tag at N-terminus.The DDIT3 is purified by proprietary chromatographic techniques. Introduction: DDIT3 reduces DNA-binding activity of C/EBP and lap by forming heterodimers which don't bind DNA. DDIT3, also known as GADD153, is a basic domain-leucine zipper(bZIP) transcription factor of C/EBP family. DDIT3 protein is up-regulated by several stresses, such as amino acid or glucose starvation, endoplasmic reticulum (ER) stress, osmotic stress and hypoxia. DDIT3 protein is invloved in ER stress-mediated apoptosis and in disease including diabetes, brain ischemia and neurodegenerative disease. DDIT3 plays a role in asoprisnil-induced apoptosis. Hypoglycaemia-induced necrotic cell death of neuroblastoma cells is an active process mediated via the induction of the transcription factor DDIT3. DDIT3 plays an important role in melanoma progression. HRG stimulation of mammary epithelial cells induces the expression of DDIT3 mRNA and protein and transcription of DDIT3 promoter.

304282225

NP_001181982.1

NM_001195053.1

P35638

21,700 Da

ATF-2 Transcription Factor Network Pathway 138006!!ATF4 Activates Genes Pathway 530772!!ATF6-alpha Activates Chaperone Genes Pathway 530770!!ATF6-alpha Activates Chaperones Pathway 105905!!Adipogenesis Pathway 198832!!MAPK Signaling Pathway 198779!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!Metabolism Of Proteins Pathway 106230!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862188

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

0.02 mg

205 USD