catalog number :
MBS143414
products type :
Recombinant Protein
products full name :
Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 3
products short name :
Complement C1q Tumor Necrosis Factor-Related Protein 3
products name syn :
C1QTNF3 Human; Complement C1q Tumor Necrosis Factor-Related Protein 3 Human Recombinant; Complement C1q tumor necrosis factor-related protein 3; Secretory protein CORS26; C1QTNF3; CTRP3; Cors; Corcs; CORS26; FLJ37576; Cartducin
other names :
complement C1q tumor necrosis factor-related protein 3 isoform a; Complement C1q tumor necrosis factor-related protein 3; complement C1q tumor necrosis factor-related protein 3; cartonectin; collagenous repeat-containing sequence 26 kDa protein; collagenous repeat-containing sequence of 26-kDa; secretory protein CORS26; C1q and tumor necrosis factor related protein 3; Collagenous repeat-containing sequence 26 kDa protein; CORS26; Secretory protein CORS26
products gene name :
C1QTNF3
other gene names :
C1QTNF3; C1QTNF3; CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26; CTRP3; CORS26
uniprot entry name :
C1QT3_HUMAN
purity :
The purity of C1QTNF3 is greater than 95% as determined by SDS PAGE.
form :
Human C1QTNF3 was filtered (0.4 um) and lyophilized in 0.5 mg/ml in 0.05M Acetate buffer pH4.
storage stability :
Store lyophilized C1QTNF3 at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted C1QTNF3 can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
other info2 :
Solubility: It is recommended to add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of the protein is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Complement Component
products description :
Description: C1QTNF3 Human Recombinant produced in E Coli is a single, non-glycosylated, Polypeptide chain containing 234 amino acids and having a molecular mass of 25.4 kDa. The protein contains an extra 10 aa His tag at N-terminus. The C1QTNF3 amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q9BXJ4 amino acids 23246. The C1QTNF3 is purified by proprietary chromatographic techniques. Introduction: C1QTNF3 also called Cartducin is a novel angiogenic factor in the formation of neointima following angioplasty. C1QTNF3 a paralog of Acrp30 (adiponectin). C1QTNF3 is a secretory protein produced by chondrogenic precursors & proliferating chondrocytes, and belongs to a novel C1q family of proteins. Cartducin promotes the growth of mesenchymal chondroprogenitor cells & chondrosarcoma-derived chondrocytic cells in vitro. Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways. C1QTNF3 promotes proliferation & the migration of endothelial cells.
ncbi acc num :
NP_112207.1
ncbi gb acc num :
NM_030945.3
ncbi mol weight :
35,183 Da
uniprot summary :
C1QTNF3: 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5p13. Cellular Component: extracellular space; collagen; membrane. Molecular Function: protein binding. Biological Process: fat cell differentiation; negative regulation of inflammatory response; negative regulation of gluconeogenesis; negative regulation of NF-kappaB import into nucleus; positive regulation of cytokine secretion