protein

Recombinant Human CD95, His Tag

MBS143412

0.02 mg

205 USD

Recombinant Protein

Recombinant Human CD95, His Tag

CD95

CD95 Human His; CD95 Human Recombinant, His Tag; CD95; CD-95; Tumor necrosis factor receptor superfamily member 6; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen; FAS; APT1; FAS1; TNFRSF6; APO-1; FASTM; ALPS1A; CD95 His

tumor necrosis factor receptor superfamily member 6 isoform 1; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; APO-1 cell surface antigen; CD95 antigen; Delta Fas/APO-1/CD95; FAS 827dupA; FAS receptor variant 9; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas AMA; TNF receptor superfamily member 6; apoptosis antigen 1; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6; Fas cell surface death receptor; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95

CD95

FAS; FAS; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; APT1; FAS1; TNFRSF6

TNR6_HUMAN

E Coli

335

Greater than 95% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M b-ME. Sterile liquid formulation.

CD95 although stable at 10 degree C for 5 days, should be stored below -18 degree C.Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; CD Antigens

Description: Recombinant FAS antigen/ CD95 purified from E Coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids.The FAS antigen is purified by proprietary chromatographic techniques. Introduction: FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.

4507583

NP_000034.1

NM_000043.4

P25445

24,781 Da

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

0.02 mg

205 USD