protein

Recombinant Human Baculoviral IAP Repeat-Containing 5

MBS143409

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Baculoviral IAP Repeat-Containing 5

Baculoviral IAP Repeat-Containing 5

BIRC5 Human; Baculoviral IAP Repeat-Containing 5 Human Recombinant; BIRC-5; Baculoviral IAP repeat-containing protein 5; API4; EPR-1; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; BIRC5; IAP4; Survivin

baculoviral IAP repeat-containing protein 5 isoform 2; Baculoviral IAP repeat-containing protein 5; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; apoptosis inhibitor survivin; survivin variant 3 alpha; baculoviral IAP repeat containing 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin

BIRC5

BIRC5; BIRC5; API4; EPR-1; API4; IAP4

BIRC5_HUMAN

E Coli

137

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SHMGAPTLPP AWQPFLKDHR ISTFKNWPFL EGCACTPERM AEAGFIHCPT ENEPDLAQCF FCFKELEGWE PDDDPIEEHK KHSSGCAFLS VKKQFEELTL GEFLKLDRER AKNKIAKETN NKKKEFEETA KKVRRAIEQL AAMD.

Greater than 90.0% as determined by SDS-PAGE.

The BIRC5 solution contains 20mM Tris-HCl pH-7.5 & 0.1M NaCl. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Baculoviral IAP Repeat-Containing

Description: Survivin Human Recombinant fused to a 152 a.a. N-terminal CaM-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 294 amino acids (1-142 a.a.) and having a molecular mass of 33 kDa. Introduction: Survivin is part of the of the inhibitor of apoptosis (IAP) family, which encodes negative regulatory proteins that prevent apoptotic cell death. Members of the IAP family include multiple baculovirus IAP repeat (BIR) domains, but Survivin has only a single BIR domain. Survivin is an inhibitor of caspase activation therefore leading to negative regulation of apoptosis. BIRC5 is expressed in Merkel cell carcinoma.BIRC5 polymorphism causes survivin expression, thus contributing to the genetic susceptibility to lung cancer. BIRC5 expression in large cell lung cancer is substantially higher than in normal tissue cells. Survivin mRNA is up-regulated in tumors. Apoptotic response of infected intestinal epithelial cells is suppressed by C. parvum via upregulation of BIRC5, favoring parasite infection. Up-regulation of of Survivin is associated with breast carcinomas.BIRC5 increases the activity of an oncolytic adenovirus in the presence of low-dose radiotherapy. ER- breast cancer cells become dependent on Notch-survivin signaling for their maintenance, in vivo. Survivin mRNA positive cases are related with bladder tumour recurrence elevated expression of survivin might play an important role of development in nasal polyps.

59859880

NP_001012270.1

NM_001012270.1

O15392

8,490 Da

Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822); Aurora A Signaling Pathway (137925); Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); FOXM1 Transcription Factor Network Pathway (137935); Hepatitis B Pathway (694606)

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 17q25. Cellular Component: centriole; nuclear chromosome; microtubule; spindle microtubule; cytoplasmic microtubule; cytoplasm; spindle; midbody; nucleus; interphase microtubule organizing center; cytosol; chromosome, pericentric region. Molecular Function: tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; metal ion binding; microtubule binding; caspase inhibitor activity; ubiquitin-protein ligase activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding; cobalt ion binding. Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; establishment of chromosome localization; cytokinesis; regulation of signal transduction; protein ubiquitination; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of exit from mitosis; negative regulation of apoptosis

0.005 mg

140 USD

0.025 mg

205

1 mg

2665