Recombinant Mouse BH3 Interacting Domain Death Agonist p15 | MyBioSource MBS143408 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse BH3 Interacting Domain Death Agonist p15

catalog :

MBS143408

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143408

products type :

Recombinant Protein

products full name :

Recombinant Mouse BH3 Interacting Domain Death Agonist p15

products short name :

BH3 Interacting Domain Death Agonist p15

products name syn :

tBID Mouse; Truncated BH3 Interacting Domain Death Agonist Mouse Recombinant; Truncated BH3-interacting domain death agonist; p22 BID; BID; FP497; MGC15319; MGC42355; tBID

other names :

BH3-interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist; p22 BID; BH3 interacting domain death agonist; p22 BID; BID

products gene name :

mtBID

other gene names :

Bid; Bid; AI875481; AU022477; 2700049M22Rik; BID

uniprot entry name :

BID_MOUSE

host :

E Coli

sequence length :

195

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The Mouse Truncated BID protein solution contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl. Sterile Filtered colorless liquid formulation (0.1mg/1ml).

concentration :

0.1mg/1ml

storage stability :

Store at 4 degree C if entrie vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer period of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; BID

products description :

Description: Truncated BID Mouse Recombinant also called BH3-interacting domain death agonist p15 produced in E Coli is a single, non-glycosylated polypeptide chain containing 61-195 amino acids (135 a.a.) and having a molecular mass of 15.4 kDa. Introduction: Truncated BH3 interacting domain death agonist is a truncated form of the pro-apoptotic full-length BID. Truncated BH3 interacting domain death agonist is generated by Caspase-8 cleavage of BID. The truncated form of the protein translocates from the cytosol to mitochondria and transduces apoptotic signals. BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.

ncbi gi num :

31542228

ncbi acc num :

NP_031570.2

ncbi gb acc num :

NM_007544.3

uniprot acc num :

P70444

ncbi pathways :

Activation And Oligomerization Of BAK Protein Pathway (1111511); Activation Of BAD And Translocation To Mitochondria Pathway (1111505); Activation Of BH3-only Proteins Pathway (1111504); Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway (1111503); Activation, Translocation And Oligomerization Of BAX Pathway (1111510); Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Amyotrophic Lateral Sclerosis (ALS) Pathway (83296); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198339)

uniprot summary :

BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found. Protein type: Mitochondrial; Apoptosis. Cellular Component: membrane; mitochondrion; cell; cytoplasm; intracellular; cytosol. Molecular Function: protein binding; ubiquitin protein ligase binding. Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of apoptosis; positive regulation of protein homooligomerization; apoptosis; DNA damage response, signal transduction; regulation of protein oligomerization; regulation of cell proliferation; regulation of apoptosis; positive regulation of protein oligomerization; apoptotic mitochondrial changes; protein targeting to mitochondrion; protein homooligomerization

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage