product summary
Loading...
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human B-Cell Leukemia/Lymphoma 2 -NWGR
catalog :
MBS143400
quantity :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143400
products type :
Recombinant Protein
products full name :
Recombinant Human B-Cell Leukemia/Lymphoma 2 -NWGR
products short name :
B-Cell Leukemia/Lymphoma 2 -NWGR
products name syn :
Bcl 2 Human (minus NWGR domain); B-Cell Leukemia/Lymphoma 2 Human Recombinant (NWGR); Apoptosis regulator Bcl-2; BCL2; B-cell CLL/lymphoma 2; Bcl-2; Bcl-2 -NWGR
other names :
apoptosis regulator Bcl-2 alpha isoform; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2
products gene name :
Bcl-2 -NWGR
other gene names :
BCL2; BCL2; Bcl-2; PPP1R50
uniprot entry name :
BCL2_HUMAN
host :
E Coli
sequence length :
239
purity :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Bcl-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Bcl-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
tested application :
Western Blot (WB)
app notes :
Input marker or positive control (Western Blotting).Function study.
other info2 :
Solubility: Suspend Bcl-2 in 100ul of 0.5M Acetic acid, over night at 4 degree C. Dilute 10 fold into selected buffer system.BCL-2 has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; B Cell Lymphoma
products description :
Description: Bcl-2 Des NWGR domain (143-146 residues) Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 214 amino acids 1-142 and 147-218.The Bcl-2 is expressed as His-Tag fusion protein and purified by proprietary chromatographic techniques. Introduction: BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
ncbi gi num :
72198189
ncbi acc num :
NP_000624.2
ncbi gb acc num :
NM_000633.2
uniprot acc num :
P10415
ncbi mol weight :
22,337 Da
ncbi pathways :
ATF-2 Transcription Factor Network Pathway 138006!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Apoptosis Pathway 198797!!Apoptosis Pathway 83060
ncbi summary :
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
size :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!