Recombinant Human Tyr- 3/Trp-5 Mmonooxygenase Activation protein, Zeta | MyBioSource MBS143386 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Tyr- 3/Trp-5 Mmonooxygenase Activation protein, Zeta

catalog :

MBS143386

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143386

products type :

Recombinant Protein

products full name :

Recombinant Human Tyr- 3/Trp-5 Mmonooxygenase Activation protein, Zeta

products short name :

Tyr- 3/Trp-5 Mmonooxygenase Activation protein

products name syn :

YWHAZ Human; Tyr-3/Trp- 5 Monooxygenase Activation Protein Zeta Human Recombinant; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; Tyr-3/Trp- 5 Monooxygenase Activation Protein Zeta; 14-3-3 Zeta

other names :

14-3-3 protein zeta/delta; 14-3-3 protein zeta/delta; 14-3-3 protein zeta/delta; 14-3-3 delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; epididymis luminal protein 4; epididymis secretory protein Li 3; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta; Protein kinase C inhibitor protein 1; KCIP-1

products gene name :

YWHAZ

other gene names :

YWHAZ; YWHAZ; HEL4; YWHAD; KCIP-1; HEL-S-3; 14-3-3-zeta; KCIP-1

uniprot entry name :

1433Z_HUMAN

host :

E Coli

sequence length :

245

sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDK NELVQKAKLA EQAERYDDMA ACMKSVTEQG AELSNEERNL LSVAYKNVVG ARRSSWRVVS SIEQKTEGAE KKQQMAREYR EKIETELRDI CNDVLSLLEK FLIPNASQAE SKVFYLKMKG DYYRYLAEVA AGDDKKGIVD QSQQAYQEAF EISKKEMQPT HPIRLGLALN FSVFYYEILN SPEKACSLAK TAFDEAIAEL DTLSEESYKD STLIMQLLRD NLTLWTSDTQ GDEAEAGEGG EN.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

YWHAZ solution containing 1x PBS pH-7. Sterile filtered colorless solution.

products categories :

PROTEIN KINASES; Enzymes; 14-3-3

products description :

Description: YWHAZ fused to His Tag on N-terminus Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 245amino acids (1-245) and having a molecular mass of 32 kDa. YWHAZ is purified by proprietary chromatographic techniques. Introduction: YWHAZ accession number NP_ 663723 belongs to the 14-3-3 family of proteins which are in charge for checkpoint control, apoptotic & nutrient sensing pathways as well as signal transduction by binding to phosphoserine-containing proteins. The 14-3-3 protein family is found in both plants and mammals, and KCIP-1 protein is 99% identical to the mouse, rat and sheep orthologs. KCIP-1 interacts with IRS1 protein, signifying a role in regulating insulin. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least 7 isoforms, ?, ?, ?, ?, ?, ? and ? that have been identified in mammals. YWHAZ function as an adapter protein involved in the regulation of a large spectrum of both general and specialized signaling pathway. YWHAZ binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

ncbi gi num :

208973238

ncbi acc num :

NP_001129171.1

ncbi gb acc num :

NM_001135699.1

uniprot acc num :

P63104

ncbi mol weight :

19,333 Da

ncbi pathways :

Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Adaptive Immune System Pathway (366160); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Calcium Regulation In The Cardiac Cell Pathway (198906); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Class I PI3K Signaling Events Mediated By Akt Pathway (138020)

ncbi summary :

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

uniprot summary :

14-3-3 zeta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 8q23.1. Cellular Component: extracellular space; protein complex; mast cell granule; cytoplasmic vesicle membrane; focal adhesion; mitochondrion; leading edge; postsynaptic density; cytosol; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus. Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein complex binding; protein kinase binding; transcription factor binding. Biological Process: response to drug; platelet activation; histamine secretion by mast cell; establishment of Golgi localization; apoptosis; gene expression; signal transduction; blood coagulation; protein targeting to mitochondrion; negative regulation of apoptosis

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

3490

more info or order :

MyBioSource product webpage