Recombinant Human Inhibin-Alpha | MyBioSource MBS143383 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Inhibin-Alpha

catalog :

MBS143383

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143383

products type :

Recombinant Protein

products full name :

Recombinant Human Inhibin-Alpha

products short name :

Inhibin-Alpha

products name syn :

Inhibin a Human; Inhibin Alpha Human Recombinant; Inhibin a

other names :

inhibin alpha chain preproprotein; Inhibin alpha chain; inhibin alpha chain; A-inhibin subunit; inhibin, alpha

other gene names :

INHA; INHA

uniprot entry name :

INHA_HUMAN

host :

E Coli

sequence length :

366

sequence :

PNLSLPVPGAPPTPAQPYSLLPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI. Beta Chain:. GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR GHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS.
STPLMSWPWSPSALRLLQRPPEEPAAHANCHRVALNISF
QELGWERWIVYPPSFIFHYCHGGCGLHIP
Alpha chain:.

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Inhibin-A alpha chain is supplied in 1x PBS and 50% glycerol. Physical Appearance: Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.

products categories :

HORMONES; Hormones; Inhibin A

products description :

Description: Inhibin-Alpha Human Recombinant produced in E Coli is a non-glycosylated, polypeptide chain containing 264 amino acids comprising of both A and B chains, having a molecular mass of 33.5 kDa.The Inhibin-Alpha is fused with an amino-terminal hexahistidine tag. The Inhibin-Alpha is purified by standard chromatographic techniques. Introduction: Inhibins are dimeric peptide hormones produced by female ovarian granulose cells and male Sertoli cells as well as a variety of other tissues. Inhibins have two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits.Inhibins are thought to inhibit the production of follicle-stimulating hormone (FSH) by the pituitary gland. In addition, Inhibins are also thought to play a role in the control of gametogenesis, and embryonic and fetal development.

ncbi gi num :

4504697

ncbi acc num :

NP_002182.1

ncbi gb acc num :

NM_002191.3

uniprot acc num :

P05111

ncbi mol weight :

39,670 Da

ncbi pathways :

Glycoprotein Hormones Pathway (160989); Metabolism Of Proteins Pathway (106230); Ovarian Infertility Genes Pathway (198801); Peptide Hormone Biosynthesis Pathway (160988); Peptide Hormone Metabolism Pathway (771603)

ncbi summary :

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

uniprot summary :

INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q35. Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cell soma; extracellular region. Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: negative regulation of B cell differentiation; hemoglobin biosynthetic process; nervous system development; regulation of cell cycle; male gonad development; signal transduction; regulation of cell proliferation; negative regulation of interferon-gamma biosynthetic process; negative regulation of cell cycle; negative regulation of follicle-stimulating hormone secretion; response to external stimulus; regulation of apoptosis; cell surface receptor linked signal transduction; negative regulation of macrophage differentiation; ovarian follicle development; cell-cell signaling; regulation of MAPKKK cascade; erythrocyte differentiation; negative regulation of phosphorylation; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell cycle arrest; skeletal development; cell development

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5435

more info or order :

MyBioSource product webpage