Recombinant Human Kallikrein-1 | MyBioSource MBS143369 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Kallikrein-1

catalog :

MBS143369

quantity :

0.02 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143369

products type :

Recombinant Protein

products full name :

Recombinant Human Kallikrein-1

products short name :

Kallikrein-1

products name syn :

KLK1 Human; Kallikrein-1 Human Recombinant; KLK1; KLK-1; HK1; HK-1; KLKR; KLK6; Tissue Kallikrein; hKLK1; EC 3.4.21.35; Kidney/pancreas/salivary gland kallikrein; Kallikrein-1

other names :

kallikrein-1 preproprotein; Kallikrein-1; kallikrein-1; glandular kallikrein 1; kallikrein 1, renal/pancreas/salivary; kallikrein serine protease 1; kidney/pancreas/salivary gland kallikrein; tissue kallikrein; kallikrein 1; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein

products gene name :

KLK1

other gene names :

KLK1; KLK1; hK1; KLKR; Klk6

uniprot entry name :

KLK1_HUMAN

host :

Pichia Pastoris

sequence length :

262

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Ile-Val-Gly-Gly-Trp-Glu.

purity :

Greater than 98.0% as determined by both:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a solution containing 1xPBS. Sterile Filtered white lyophilized powder.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized KLK1 in sterile 18M-cm H2O not less than 100 ug/ml or more than 10 mg/ml solutions. Biological Activity: Human Kallikrein-1 active Unit Definitin: 1 unit will hydrolyze 1 umole of H-D-Val-Leu-Arg-pNA(S-2266) per minute at pH 8.0 at 37 degree C Human Kallikrein-1 measured biological activity of no less than 5 Units/mg (S2266 method).

products categories :

ENZYMES; Enzymes; Kallikrein

products description :

Description: KLK1 Human Recombinant produced in Yeast is a single, glycosylated, polypeptide chain containing 238 amino acids and having a molecular mass of 28-32 kDa.KLK1 Human Recombinant is purified by proprietary chromatographic techniques. Introduction: Kallikreins are serine protease enzymes having various physiological functions. Kallikreins are implicated in carcinogenesis and have potenital as novel cancer disease biomarkers. KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.Human Kallikrein-1, also called as Kallidinogenase, Kininogenase or Kininogenin, is an active protein enzyme present in saliva, pancreatic juices, and urine that catalyzes the proteolysis of bradykininogen to bradykinin. Kallikrein-1, which derived from human or porcine, have been used as drugs for a long time, they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels. KLK1 demonstrates both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1, Ser/Arg strongly preferred at P1', and Phe/Leu at P2. rs5517 in the KLK1 gene is considerably connected with hypertension in a Chinese Han population. KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins. The K allele of KLK1 promoter and TT genotype of TGF-beta1 are a genetic KLK1 -130 GN and -128 G-C, and the defenselessness factor contributing to progressive renal descent in Taiwanese primary vesicoureteric reflux children. Induction of KLK1 in carotid arteriosclerosis doesn't lead to kallikrein-kinins pathway activation. Transgenic rats expressing KLK1 have impaired renal response to acute volume expansion Endothelial cells synthesize and release active form of KLK1on the surface which is important function in maintenance of circulation homeostasis. KLK1 participates in epidermal desquamation through cleavage of desmoglein 1 and regulation by lympho-epithelial Kazal-type-related inhibitor (LEKTI).

ncbi gi num :

4504875

ncbi acc num :

NP_002248.1

ncbi gb acc num :

NM_002257.3

uniprot acc num :

P06870

ncbi mol weight :

23,835 Da

ncbi pathways :

Blood Clotting Cascade Pathway 198840!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213307!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213276!!Metabolism Of Proteins Pathway 106230!!Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908

ncbi summary :

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]

size :

0.02 mg

price :

140 USD

more info or order :

MyBioSource product webpage