Recombinant Human Cyclophilin-D | MyBioSource MBS143357 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cyclophilin-D

catalog :

MBS143357

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143357

products type :

Recombinant Protein

products full name :

Recombinant Human Cyclophilin-D

products short name :

Cyclophilin-D

products name syn :

Cyclophilin D Human; Cyclophilin-D Human Recombinant; Peptidylprolyl isomerase D; PPID; CYPD; CYP-40; 40 kDa peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase; Cyclophilin-40; CYP40; Cyclophilin-related protein; MGC33096; EC 5.2.1.8; Cyclophilin D

other names :

peptidyl-prolyl cis-trans isomerase D; Peptidyl-prolyl cis-trans isomerase D; peptidyl-prolyl cis-trans isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase D; PPIase D; cyclophilin 40; cyclophilin D; cyclophilin-40; cyclophilin-related protein; rotamase D; peptidylprolyl isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; Rotamase D

other gene names :

PPID; PPID; CYPD; CYP-40; CYP40; CYPD; PPIase D; CYP-40

uniprot entry name :

PPID_HUMAN

host :

E Coli

sequence length :

370

sequence :

MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFFDVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSMANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGEKPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL RYVDSSKAVI ETADRAKLQPIALSCVLNIG ACKLKMSNWQ GAIDSCLEAL ELDPSNTKAL YRRAQGWQGLKEYDQALADL KKAQGIAPED KAIQAELLKV KQKIKAQKDK EKAVYAKMFA.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

1mg/ml solution containing 1x PBS pH-7.4 & 10% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

other info2 :

Biological Activity: Specific activity is > 210 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

products categories :

ENZYMES; Enzymes; Cyclophilin

products description :

Description: Cyclophilin-D Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (amino acids 1-370) containing 390 amino acids and having a molecular mass of 42.9kDa. Cyclophilin-D is fused to a 20 aa His Tag at N-terminus and is purified by proprietary chromatographic techniques. Introduction: Cyclophilin-D is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and speeds up the protein folding. Cyclophilin-D possess PPIase activity and binds to the immunosuppressant cyclosporin-A. Cyclophilin-D is very well known that its overexpression suppresses the apoptosis in cancer cell. Cyclophilin-D suppresses apoptotic cell death by the use of mitochondrial hexokinase-2 dependent mechanism in cancer cells.

ncbi gi num :

4826932

ncbi acc num :

NP_005029.1

ncbi gb acc num :

NM_005038.2

uniprot acc num :

Q08752

ncbi mol weight :

40,764 Da

ncbi pathways :

C-MYB Transcription Factor Network Pathway (138073)

ncbi summary :

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

uniprot summary :

PPID: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIase D subfamily. Protein type: Nucleolus; EC 5.2.1.8; Isomerase. Chromosomal Location of Human Ortholog: 4q31.3. Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus. Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; heat shock protein binding; estrogen receptor binding; Hsp90 protein binding; Hsp70 protein binding; cyclosporin A binding; transcription factor binding. Biological Process: release of virus from host; protein transport; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; positive regulation of protein secretion; protein folding; apoptosis; positive regulation of apoptosis; protein complex assembly; negative regulation of transcription from RNA polymerase II promoter

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

3490

more info or order :

MyBioSource product webpage