protein

Recombinant Human Cathepsin-L

MBS143355

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Cathepsin-L

Cathepsin-L

Cathepsin L, CTSL1, Cathpsin L1, Major Excreted Protein, MEP, EC3.4.22.15, CATL, EC 3.4.22

cathepsin L1 isoform 1 preproprotein; Cathepsin L1; cathepsin L1; major excreted protein; cathepsin L; Cathepsin L; Major excreted protein; MEP

CTSL

CTSL; CTSL; MEP; CATL; CTSL1; CTSL1; MEP

CATL1_HUMAN

E. coli

333

MGSSHHHHHH SSGLVPRGSH MGSTLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV

Greater than 90% as determined by SDS-PAGE.

CTSL protein solution containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.

1mg/mL

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.

Physical Appearance: Sterile filtered colorless solution.

ENZYMES

CTSL Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 339 amino acids (18-333 a.a) and having a molecular mass of 38.3kDa. CTSL is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

384081592

NP_001244900.1

NM_001257971.1

37,564 Da

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Endosomal/Vacuolar Pathway (477125)

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

CTSL1: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family. Protein type: Motility/polarity/chemotaxis; EC 3.4.22.15; Protease. Chromosomal Location of Human Ortholog: 9q21.33. Cellular Component: extracellular space; lysosomal lumen; lysosome; extracellular region; nucleus. Molecular Function: collagen binding; protein binding; proteoglycan binding; histone binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity. Biological Process: extracellular matrix disassembly; antigen processing and presentation; collagen catabolic process; extracellular matrix organization and biogenesis; adaptive immune response; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; innate immune response; proteolysis

0.005 mg

140 USD

0.02 mg

205

1 mg

2665