product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Pigment Epithelium-Derived Factor, HEK
catalog :
MBS143338
quantity :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143338
products type :
Recombinant Protein
products full name :
Recombinant Human Pigment Epithelium-Derived Factor, HEK
products short name :
Pigment Epithelium-Derived Factor
products name syn :
PEDF Human, HEK; Pigment Epithelium-Derived Factor Human Recombinant, HEK; Pigment epithelium-derived factor; PEDF; Serpin-F1; SerpinF1; EPC-1; EPC1; PIG35; PEDF HEK
other names :
pigment epithelium-derived factor; Pigment epithelium-derived factor; pigment epithelium-derived factor; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1
products gene name :
PEDF
other gene names :
SERPINF1; SERPINF1; OI6; OI12; PEDF; EPC-1; PIG35; PEDF; PEDF
uniprot entry name :
PEDF_HUMAN
host :
HEK 293
sequence length :
418
purity :
Greater than 95% as determined by SDS-PAGE.
form :
The filtered (0.4 um) concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 20mM NaCl pH-7.5. Filtered White lyophilized (freeze-dried) powder.
storage stability :
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time.
other info2 :
Solubility: It is recomnded to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
products categories :
CYTOKINES AND GROWTH FACTORS; Neurotrophins; Pigment Epithelium-Derived Factor
products description :
Description: PEDF Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing a total of 410 amino acids, having a molecular mass of 45.6 kDa and fused to an 11 aa FLAG tag at C-Terminus.The Human PEDF is purified by proprietary chromatographic techniques. Introduction: PEDF is a neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. SerpinF1 is a potent inhibitor of angiogenesis. EPC1 doesn't undergo the stressed to relaxed conformation transition characteristic as of the active serpins since it exhibits no serine protease inhibitory activity.Aqueous humour level of asymmetric dimethylarginine is correlated with PEDF in humans. ADMA and PEDF levels are increased in response to inflammation in uveitis.Lack of PEDF expression is a potent factor for the enhancement of tumor growth and angiogenesis in breast cancer.PEDF & VEGF genes contribute to the development of diabetic retinopathy.PEDF and VEGF structural changes in blood vessel wall play an important role in the pathophysiology of PD patients.PEDF-overexpressing tumors exhibited reduced intratumoral angiogenesis.SerpinF1 is a new promising approach for the treatment of osteosarcoma. Levels of the natural ocular anti-angiogenic factor SentrinF1 (PEDF) is associated with proliferative retinopathy.VEGF secreted by retinal pigment epithelial cells upregulates PEDF expression via VEGFR-1 in an autocrine manner. Sentrin-F1 concentration in the aqueous humor of diabetic patients predicts who will develop progression of retinopathy.PEDF blocks angiogenic effects of leptin through its anti-oxidative properties.
ncbi gi num :
39725934
ncbi acc num :
NP_002606.3
ncbi gb acc num :
NM_002615.5
uniprot acc num :
P36955
ncbi mol weight :
46,312 Da
ncbi summary :
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
size :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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