product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Platelet Derived Growth Factor-AA, Yeast
catalog :
MBS143334
quantity :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143334
products type :
Recombinant Protein
products full name :
Recombinant Human Platelet Derived Growth Factor-AA, Yeast
products short name :
Platelet Derived Growth Factor-AA
products name syn :
PDGF AA Human, Yeast; Platelet-derived Growth Factor AA Human Recombinant, Yeast; Glioma-derived growth factor; GDGF; Osteosarcoma-derived Growth Factor; ODGF; PDGF-AA; PDGF-1; PDGF AA Yeast
other names :
platelet-derived growth factor subunit A isoform 1 preproprotein; Platelet-derived growth factor subunit A; platelet-derived growth factor subunit A; PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; platelet-derived growth factor alpha polypeptide; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
products gene name :
PDGF AA
other gene names :
PDGFA; PDGFA; PDGF1; PDGF-A; PDGF1; PDGF subunit A
uniprot entry name :
PDGFA_HUMAN
host :
Pichia Pastoris
sequence length :
211
purity :
Greater than 98.0% as determined by SDS-PAGE.
form :
The protein was lyophilized with 20mM sodium phosphate buffer. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized PDGF-AA although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PDGF-AA should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized PDGF-AA in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 was found to be 1ng/ml corresponding to a Specific Activity of 1,000,000IU/mg calculated by the ability to stimulate the proliferation of mouse 3T3 fibroblasts (PNAS 94, 10205, 1997. Biochemistry, 1996, 35, 12077).
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors; PDGF
products description :
Description: PDGF-AA Human Recombinant produced in Yeast is a homodimeric, glycosilated, polypeptide chain containing 2 x 110 amino acids and having a total molecular mass of 34 kDa. PDGF-AA is purified by proprietary chromatographic techniques. Introduction: PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.
ncbi gi num :
77695917
ncbi acc num :
NP_002598.4
ncbi gb acc num :
NM_002607.5
uniprot acc num :
P04085
ncbi mol weight :
22,253 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Ceramide Signaling Pathway 138023!!Choline Metabolism In Cancer Pathway 1059539!!Choline Metabolism In Cancer Pathway 1084232!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550
ncbi summary :
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
size :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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