product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Vascular Endothelial Growth Inhibitor, His Tag
catalog :
MBS143312
quantity :
0.02 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143312
products type :
Recombinant Protein
products full name :
Recombinant Human Vascular Endothelial Growth Inhibitor, His Tag
products short name :
Vascular Endothelial Growth Inhibitor
products name syn :
VEGI Human, His; Vascular Endothelial Growth Inhibitor, His Tag Human Recombinant; Tumor necrosis factor ligand superfamily member 15; TNFSF-15; TNFSF15; TNF ligand-related molecule 1; VEGI; TL-1; TL1; TL1A; VEGI192A; VEGI-192; MGC129934; MGC129935; VEGI His
other names :
tumor necrosis factor ligand superfamily member 15 isoform VEGI-192; Tumor necrosis factor ligand superfamily member 15; tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A; tumor necrosis factor (ligand) superfamily, member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitorCleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form
products gene name :
VEGI
other gene names :
TNFSF15; TNFSF15; TL1; TL1A; VEGI; VEGI192A; TL1; VEGI
uniprot entry name :
TNF15_HUMAN
host :
E Coli
sequence length :
192
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
The VEGI solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 50% glycerol, 1mM DTT and 0.2M NaCl. Sterile Filtered colorless solution.
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors; VEGF
products description :
Description: VEGI Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 201 amino acids(72-251a.a.) and having a molecular mass of 22.7kDa. The VEGI is purified by proprietary chromatographic techniques. Introduction: TNFSF15 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of TNFSF15 is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. TNFSF15 is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
ncbi gi num :
324072728
ncbi acc num :
NP_001191273.1
ncbi gb acc num :
NM_001204344.1
uniprot acc num :
O95150
ncbi mol weight :
20,131 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Senescence And Autophagy Pathway 198780
ncbi summary :
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
size :
0.02 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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