product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Rat Fibroblast Growth Factor-basic
catalog :
MBS143301
quantity :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143301
products type :
Recombinant Protein
products full name :
Recombinant Rat Fibroblast Growth Factor-basic
products short name :
Fibroblast Growth Factor-basic
products name syn :
FGF 2 Rat; Fibroblast Growth Factor-basic Rat Recombinant; HBGH-2; HBGF-2; Prostatropin; FGF-2; FGB-b; Fibroblast Growth Factor-basic; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2
other names :
fibroblast growth factor 2; Fibroblast growth factor 2; fibroblast growth factor 2; HBGF-2; basic fibroblast growth factor; heparin-binding growth factor 2; fibroblast growth factor 2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
products gene name :
rFGF 2
other gene names :
Fgf2; Fgf2; bFGF; Fgf-2; Fgf-2; FGF-2; bFGF; HBGF-2
uniprot entry name :
FGF2_RAT
host :
E Coli
sequence length :
154
sequence :
PALPEDGGGA FPPGHFKDPK RLYCKNGGFF LRIHPDGRVD GVREKSDPHV KLQLQAEERG VVSIKGVCAN RYLAMKEDGR LLASKCVTEE CFFFERLESN NYNTYRSRKY SSWYVALKRT GQYKLGSKTG PGQKAILFLP MSAKS.
purity :
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
FGF-b was lyophilized from 1 mg/ml solution after extensive dialysis against 20mM phosphate buffer, pH 7.4 and 150mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Rat bFGF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Rat FGF-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Rat bFGF in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 range as determined by the dose-dependant proliferation of BALB/3T3 cells was found to be less than 0.2 ng/ml, corresponding to a specific activity of 5,000,000 IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor
products description :
Description: bFGF Rat Recombinant (FGF-2) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 145 amino acids and having a molecular mass of 16.3 kDa.The bFGF2 is purified by proprietary chromatographic techniques. Introduction: FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
ncbi gi num :
9506599
ncbi acc num :
NP_062178.1
ncbi gb acc num :
NM_019305.2
uniprot acc num :
P13109
ncbi mol weight :
17,139 Da
ncbi pathways :
Activated Point Mutants Of FGFR2 Pathway 1121869!!Adaptive Immune System Pathway 1121508!!Constitutive PI3K/AKT Signaling In Cancer Pathway 1121891!!DAP12 Interactions Pathway 1121612!!DAP12 Signaling Pathway 1121613!!Disease Pathway 1121849!!Downstream Signal Transduction Pathway 1120667!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 1121522!!Downstream Signaling Of Activated FGFR Pathway 1120598!!Endochondral Ossification Pathway 219771
ncbi summary :
activates the MAP kinase signaling pathway; plays a role in synaptic transmission; induces cell proliferation [RGD, Feb 2006]
size :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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