Recombinant Human Beta Defensin -1 | MyBioSource MBS143288 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Beta Defensin -1

catalog :

MBS143288

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143288

products type :

Recombinant Protein

products full name :

Recombinant Human Beta Defensin -1

products short name :

Beta Defensin -1

products name syn :

BD 1 Human; Beta Defensin-1 Human Recombinant; Beta-defensin 1; BD-1; Defensin beta 1; hBD-1; HBD1; HBP1; DEFB1; HBD-1; HBP-1; DEFB101; DEFB-1; MGC51822

other names :

beta-defensin 1 preproprotein; Beta-defensin 1; beta-defensin 1; BD-1; beta defensin 1; beta-defensin-1; defensin, beta 1; Defensin, beta 1

products gene name :

BD 1

other gene names :

DEFB1; DEFB1; BD1; HBD1; DEFB-1; DEFB101; BD1; HBD1; BD-1; hBD-1

uniprot entry name :

DEFB1_HUMAN

host :

E Coli

sequence length :

sequence :

GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK.

purity :

Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The Human BD-1 was lyophilized from a concentrated (1mg/ml) solution containing 20mM PBS pH-7.4 and 130mM sodium chloride. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Beta Defensin-1 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BD-1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Beta Defensin-1 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000ng/ml corresponding to a specific activity of 1,000-10,000IU/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Beta Defensin

products description :

Description: Beta Defensin-1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 47 amino acids and having a molecular mass of 5 kDa.The BD-1 is purified by proprietary chromatographic techniques. Introduction: The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. Variation in human Beta Defensin-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human Beta Defensin-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. The expression of Human BD1 is correlated with induction profiles in gingival keratinocytes. The level of expression of human DEFB1 mRNA is lower than that of human BD3 and human BD-2 in reconstructed epidermis.Human BD1 is down-regulated in human prostatic and renal carcinomas.

ncbi gi num :

4885181

ncbi acc num :

NP_005209.1

ncbi gb acc num :

NM_005218.3

uniprot acc num :

P60022

ncbi mol weight :

7,420 Da

ncbi pathways :

Beta Defensins Pathway (530759); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)

ncbi summary :

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

uniprot summary :

defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family. Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; innate immune response in mucosa; response to bacterium; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage