protein

Recombinant Mouse Macrophage Inflammatory protein-3 alpha (CCL20)

MBS143277

0.005 mg

140 USD

Recombinant Protein

Recombinant Mouse Macrophage Inflammatory protein-3 alpha (CCL20)

Macrophage Inflammatory protein-3 alpha

MIP 3a Mouse; Macrophage Inflammatory Protein-3 alpha Mouse Recombinant (CCL20); mMIP 3a; Small inducible cytokine A20 precursor; CCL20; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Liver and activation- regulated chemokine; CC chemokine LARC; Beta chemokine exodus-1; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; CC chemokine ST38; exodus-1

C-C motif chemokine 20 isoform 2; C-C motif chemokine 20; C-C motif chemokine 20; CC chemokine LARC; CC chemokine ST38; MIP-3-alpha; beta chemokine exodus-1; beta-chemokine exodus-1; liver and activation-regulated chemokine; macrophage inflammatory protein 3 alpha; small inducible cytokine subfamily A20; small-inducible cytokine A20; chemokine (C-C motif) ligand 20; Beta-chemokine exodus-1; CC chemokine LARC; CC chemokine ST38; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20

mMIP 3alpha

Ccl20; Ccl20; CKb4; LARC; ST38; MIP3A; MIP-3A; Scya20; MIP-3[a]; exodus-1; Larc; Scya20; MIP-3-alpha

CCL20_MOUSE

E Coli

96

ASNYDCCLSY IQTPLPSRAI VGFTRQMADE ACDINAIIFH TKKRKSVCAD PKQNWVKRAV NLLSLRVKKM.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized MIP-3a although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL-20 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized MIP-3a in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The Activity is calculated by its ability to chemoattract primary human T cells at 2-20ng/ml, corresponding to a specific activity of 50,000-500,000 units/mg.

CHEMOKINES; Chemokines; MIP

Description: Macrophage Inflammatory Protein-3 alpha Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa. The MIP-3a is purified by proprietary chromatographic techniques. Introduction: CCL20 is a chemotactic factor that draws lymphocytes & neutrophils, rather than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria. MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.

229092240

NP_001153210.1

NM_001159738.1

O89093

10,755 Da

Chemokine Receptors Bind Chemokines Pathway (1110501); Chemokine Signaling Pathway (99271); Chemokine Signaling Pathway (672435); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (1110499); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1111486); Disease Pathway (1111319); EBV LMP1 Signaling Pathway (198354)

CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; chemokine activity; cytokine activity. Biological Process: immune response; positive regulation of interleukin-1 alpha biosynthetic process; chemotaxis; inflammatory response; positive regulation of nitric-oxide synthase biosynthetic process

0.005 mg

140 USD

0.02 mg

205

1 mg

2665