protein

Recombinant Human RAB5A, Member RAS Oncogene Family

MBS143260

0.005 mg

140 USD

Recombinant Protein

Recombinant Human RAB5A, Member RAS Oncogene Family

RAB5A

RAB5A Human; RAB5A Human Recombinant; Ras-related protein Rab-5A; RAB5A; RAB5

ras-related protein Rab-5A isoform 2; Ras-related protein Rab-5A; ras-related protein Rab-5A; RAS-associated protein RAB5A; RAB5A, member RAS oncogene family

RAB5A

RAB5A; RAB5A; RAB5; RAB5

RAB5A_HUMAN

E Coli

201

MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQTVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQRQASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKKLPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN.

Greater than 95.0% as determined by SDS-PAGE.

The protein solution contains 20mM Tris-HCl pH-8. Sterile Filtered colorless solution.

20ug/20ul

Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Member RAS Oncogene Family

Description: RAB5A Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 215 amino acids and having a molecular mass of 23kDa. Introduction: RAB5A is a member of RAS oncogene family. The small GTPase, RAB5A is a crucial regulatory component of the endocytic pathway. Activation of RAB5A is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex). RAB5A is required for the fusion of plasma membranes and early endosomes.

635574573

NP_001278977.1

NM_001292048.1

P20339

22,178 Da

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); EGFR1 Signaling Pathway (198782); Endocytosis Pathway (102279); Endocytosis Pathway (102181); ErbB1 Downstream Signaling Pathway (138057); Factors Involved In Megakaryocyte Development And Platelet Production Pathway (187196)

RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. Protein type: Motility/polarity/chemotaxis; G protein; G protein, monomeric; G protein, monomeric, Rab. Chromosomal Location of Human Ortholog: 3p24-p22. Cellular Component: zymogen granule membrane; protein complex; early endosome; dendrite; terminal button; phagocytic vesicle; cytosol; actin cytoskeleton; lipid raft; ruffle; recycling endosome; synaptic vesicle; cell soma; perinuclear region of cytoplasm; endocytic vesicle; axon; cytoplasm; plasma membrane; melanosome; endosome membrane; nerve terminal; endosome. Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GDP-dissociation inhibitor binding. Biological Process: regulation of long-term neuronal synaptic plasticity; intracellular protein transport; regulation of endosome size; early endosome to late endosome transport; positive regulation of smooth muscle cell proliferation; regulation of endocytosis; endocytosis; regulation of filopodium formation; Rab protein signal transduction; blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of exocytosis

0.005 mg

140 USD

0.02 mg

205

1 mg

3490