protein

Recombinant Human Regulator of Calcineurin 1

MBS143249

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Regulator of Calcineurin 1

Regulator of Calcineurin 1

RCAN1 Human; Regulator of Calcineurin 1 Human Recombinant; Calcipressin-1; Regulator of calcineurin 1; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Adapt78; RCAN1; ADAPT78; CSP1; DSC1; DSCR1; RCN1

calcipressin-1 isoform d; Calcipressin-1; calcipressin-1; Down syndrome candidate region 1; Down syndrome critical region gene 1; calcium and oxidant-inducible mRNA; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1; near DSCR proline-rich protein; regulator of calcineurin 1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1

RCAN1

RCAN1; RCAN1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78; ADAPT78; CSP1; DSC1; DSCR1; MCIP1

RCAN1_HUMAN

E Coli

171

MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGPGEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS.

Greater than 90.0% as determined by SDS-PAGE.

The protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5, 100mM NaCl and 1mM DTT. Sterile Filtered colorless solution.

RCAN1 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Regulator of Calcineurin

Description: RCAN1 Isoform-b Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids and having a molecular mass of 13 kDa. Introduction: RCAN1 encoded by a gene located in the human chromosome 21, interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. RCAN1 is located in the minimal candidate region for the Down syndrome phenotype, and is over expressed in the brain of Down syndrome fetuses. Chronic over expression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development.

549806765

NP_001272318.1

NM_001285389.2

P53805

13,291 Da

Calcium Signaling In The CD4+ TCR Pathway 137941!!MicroRNAs In Cardiomyocyte Hypertrophy Pathway 198784!!Notch-mediated HES/HEY Network Pathway 169347!!Oxytocin Signaling Pathway 952859!!Oxytocin Signaling Pathway 960764!!Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway 137953!!Thyroid Hormone Signaling Pathway 946598

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

0.02 mg

205 USD