Recombinant Human Cyclophilin-A | MyBioSource MBS143205 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cyclophilin-A

catalog :

MBS143205

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143205

products type :

Recombinant Protein

products full name :

Recombinant Human Cyclophilin-A

products short name :

Cyclophilin-A

products name syn :

Cyclophilin A Human; Cyclophilin-A Human Recombinant; Peptidylprolyl isomerase A; CYPA; CYPH; MGC12404; MGC23397; MGC117158; PPIase A; Rotamase A; PPIA; Peptidyl-prolyl cis-trans isomerase A; EC 5.2.1.8; Cyclophilin A; Cyclosporin A-binding protein; Cyclophilin A

other names :

peptidyl-prolyl cis-trans isomerase A isoform 2; Peptidyl-prolyl cis-trans isomerase A; peptidyl-prolyl cis-trans isomerase A; PPIase A; T cell cyclophilin; cyclosporin A-binding protein; epididymis secretory sperm binding protein Li 69p; rotamase A; peptidylprolyl isomerase A (cyclophilin A); Cyclophilin A; Cyclosporin A-binding protein; Rotamase APeptidyl-prolyl cis-trans isomerase A, N-terminally processed

other gene names :

PPIA; PPIA; CYPA; CYPH; HEL-S-69p; CYPA; PPIase A

uniprot entry name :

PPIA_HUMAN

host :

E Coli

sequence length :

105

sequence :

MGSSHHHHHH SSGLVPRGSH MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALSTGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSMANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIADCGQLE.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

1 mg/ml solution containing 20mM Tris-HCl 8.0, 20mM NaCl, 0.5mM DTT and 10% glycerol. Sterile filtered colorless solution.

other info2 :

Biological Activity: Specific activity is > 270 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

products categories :

ENZYMES; Enzymes; Cyclophilin

products description :

Description: Cyclophilin-A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 185 amino acids (1-165 a.a.) and having a molecular mass of 20 kDa. PPIase-A is purified by proprietary chromatographic techniques. Introduction: PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilin-A is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. Cyclophilin-A can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

ncbi gi num :

665821274

ncbi acc num :

NP_001287910.1

ncbi gb acc num :

NM_001300981.1

uniprot acc num :

P62937

ncbi mol weight :

11,418 Da

ncbi pathways :

APOBEC3G Mediated Resistance To HIV-1 Infection Pathway (106016); Assembly Of The HIV Virion Pathway (106008); Basigin Interactions Pathway (106065); Binding And Entry Of HIV Virion Pathway (105986); Budding And Maturation Of HIV Virion Pathway (106009); Cell Surface Interactions At The Vascular Wall Pathway (106062); Disease Pathway (530764); Early Phase Of HIV Life Cycle Pathway (105985); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984)

ncbi summary :

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. Protein type: EC 5.2.1.8; Cyclophilin; Isomerase; RNA-binding. Chromosomal Location of Human Ortholog: 7p13. Cellular Component: extracellular space; focal adhesion; membrane; extracellular region; cytosol; nucleus. Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; virion binding; peptide binding. Biological Process: release of virus from host; platelet activation; uncoating of virus; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; protein folding; viral reproduction; RNA-dependent DNA replication; viral infectious cycle; virus assembly; platelet degranulation; positive regulation of protein secretion; entry into host cell; blood coagulation; leukocyte migration; regulation of viral genome replication

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

2365

more info or order :

MyBioSource product webpage