catalog number :
MBS143193
products type :
Recombinant Protein
products full name :
Recombinant Human Retinol Binding Protein-4
products short name :
Retinol Binding Protein-4
products name syn :
RBP4 Human; Retinol Binding Protein-4 Human Recombinant; Retinol Binding Protein 4; RBP-4; RBP4; Plasma retinol-binding protein; PRBP; RBP
other names :
retinol-binding protein 4; Retinol-binding protein 4; retinol-binding protein 4; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; retinol binding protein 4, plasma; Plasma retinol-binding protein; PRBP; RBP
products gene name :
RBP4
other gene names :
RBP4; RBP4; RDCCAS; PRBP; RBP
uniprot entry name :
RET4_HUMAN
sequence :
MERDCRVSSF RVKENFDKAR FSGTWYAMAK KDPEGLFLQD NIVAEFSVDE TGQMSATAKGRVRLLNNWDV CADMVGTFTD TEDPAKFKMK YWGVASFLQK GNDDHWIVDT DYDTYAVQYS CRLLNLDGTC ADSYSFVFSR DPNGLPPEAQ KIVRQRQEEL CLARQYRLIV HNGYCDGRSE RNLL.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
1 mg/ml in PBS pH-7.4. Sterile Filtered colorless solution.
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors; Retinol Binding Protein
products description :
Description: RBP-4 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (19-201 a.a.) containing 184 amino acids and having a molecular mass of 21 kDa.The Retinol Binding Protein-4 is purified by proprietary chromatographic techniques. Introduction: Retinol binding protein 4(RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. This protein was found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli.RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the rbp-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
ncbi acc num :
NP_006735.2
ncbi gb acc num :
NM_006744.3
ncbi mol weight :
23,010 Da
ncbi pathways :
Disease Pathway 530764!!Diseases Associated With Visual Transduction Pathway 771581!!Retinoid Cycle Disease Events Pathway 771582!!Retinoid Metabolism And Transport Pathway 187208!!SREBP Signalling Pathway 219802!!Signal Transduction Pathway 477114!!The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway 771585!!Visual Phototransduction Pathway 771584!!Vitamin A And Carotenoid Metabolism Pathway 198785!!Retinoate Biosynthesis I Pathway 545452
ncbi summary :
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]