product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Interferon Regulatory Factor-2
catalog :
MBS143192
quantity :
0.005 mg
price :
140 USD
more info or order :
product information
catalog number :
MBS143192
products type :
Recombinant Protein
products full name :
Recombinant Human Interferon Regulatory Factor-2
products short name :
Interferon Regulatory Factor-2
products name syn :
IRF 2 Human; Interferon Regulatory Factor-2 Human Recombinant; IRF-2; IRF2; MAR; DKFZp686F0244; Interferon regulatory factor 2
other names :
interferon regulatory factor 2; Interferon regulatory factor 2; interferon regulatory factor 2; interferon regulatory factor 2
products gene name :
IRF 2
other gene names :
IRF2; IRF2; IRF-2; IRF-2
uniprot entry name :
IRF2_HUMAN
host :
E Coli
sequence length :
349
sequence :
MGSSHHHHHH SSGLVPRGSH MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMHAARHGWDVEK DAPLFRNWAI HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIKKGNNAFRVYR MLP.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
1 mg/ml in 20mM Tris pH-8, 1mM DTT and 10% Glycerol. Sterile Filtered colorless solution.
concentration :
1.0 mL @ 1.0 mg/ml
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interferon
products description :
Description: Interferon Regulatory Factor-2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 133 amino acids (1-113) with a His Tag of 20 aa, and having a molecular mass of 15 kDa.The IRF2 is purified by proprietary chromatographic techniques. Introduction: Interferon regulatory factor 2 is a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. IRF2 binds to the upstream regulatory region of type-1 IFN and IFN-inducible MHC class-1 genes (the interferon consensus sequence (ics) and represses those genes.
ncbi gi num :
153082752
ncbi acc num :
NP_002190.2
ncbi gb acc num :
NM_002199.3
uniprot acc num :
P14316
ncbi mol weight :
39,156 Da
ncbi pathways :
Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (366171); Factors Involved In Megakaryocyte Development And Platelet Production Pathway (187196); Hemostasis Pathway (106028); Immune System Pathway (106386); Innate Immune System Pathway (106387); Interferon Signaling Pathway (187103); Interferon Alpha/beta Signaling Pathway (187104); Interferon Gamma Signaling Pathway (187106); RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways (187097)
ncbi summary :
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
uniprot summary :
IRF2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 4q34.1-q35.1. Cellular Component: nucleoplasm; focal adhesion; cytoplasm; cytosol. Molecular Function: protein binding; DNA binding; transcription factor activity. Biological Process: cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; blood coagulation
size1 :
0.005 mg
price1 :
140 USD
size2 :
0.02 mg
price2 :
205
size3 :
1 mg
price3 :
3490
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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