protein

Recombinant Human Vascular Endothelial Growth Factor C

MBS143187

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Vascular Endothelial Growth Factor C

Vascular Endothelial Growth Factor C

VEGF C Human; Vascular Endothelial Growth Factor C Human Recombinant; VEGF-C; Vascular endothelial growth factor C; VRP; Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VEGFC

vascular endothelial growth factor C preproprotein; Vascular endothelial growth factor C; vascular endothelial growth factor C; FLT4 ligand DHM; vascular endothelial growth factor-related protein; vascular endothelial growth factor C; Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VRP

VEGFC

VEGFC; VEGFC; VRP; Flt4-L; LMPH1D; VEGF-C; Flt4-L; VRP

VEGFC_HUMAN

Sf9 Insect Cells

419

Greater than 90.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Each mg of VEGF-C Human contains 50mg BSA and 1xPBS as buffer. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized VEGF-C although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution VEGF-C should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized VEGF-C in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Measured by its ability to bind to the VEGFR-3/FLT-4 receptor in the Ba/F3-hVEGFR-3 assay. The ED50 in this assay is about 4ng/ml corresponding to a Specific Activity of 250,000IU/mg.

CYTOKINES AND GROWTH FACTORS; Growth Factors; VEGF

Description: VEGF-C Human Recombinant- contains 129 amino acids residues and was fused to a His- tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions. Introduction: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. Human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This proteinis a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascularendothelial cells, it is much less potent than VEGF-A.

4885653

NP_005420.1

NM_005429.4

P49767

46,883 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Heart Development Pathway (198802); Hemostasis Pathway (106028); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105)

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

VEGFC: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family. Protein type: Secreted, signal peptide; Secreted; Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q34.3. Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: protein binding; growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity. Biological Process: signal transduction; induction of positive chemotaxis; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; platelet degranulation; positive chemotaxis; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell proliferation; negative regulation of blood pressure; angiogenesis; positive regulation of cell-matrix adhesion; response to drug; substrate-bound cell migration; positive regulation of neuroblast proliferation; platelet activation; positive regulation of blood vessel endothelial cell migration; positive regulation of protein amino acid autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; positive regulation of angiogenesis; positive regulation of protein secretion; positive regulation of cell division; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of epithelial cell proliferation. Disease: Lymphedema, Hereditary, Id

0.002 mg

140 USD

0.01 mg

205

1 mg

3735