Recombinant Human Progranulin | MyBioSource MBS143184 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Progranulin

catalog :

MBS143184

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143184

products type :

Recombinant Protein

products full name :

Recombinant Human Progranulin

products short name :

Progranulin

products name syn :

PGRN Human; Progranulin Human Recombinant; GRN; PGRN; granulin; Acrogranin; propithelin; PC cell derived growth Factor; GEP; GP88; PEPI; PCDGF

other names :

granulins; Granulins; granulins; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin; granulin; Proepithelin; PEPI

products gene name :

PGRN

other gene names :

GRN; GRN; GEP; GP88; PEPI; PGRN; CLN11; PCDGF; PEPI; GP88; Glycoprotein 88

uniprot entry name :

GRN_HUMAN

host :

HEK 293 cells

sequence length :

593

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The protein solution contains 1xPBS. Sterile Filtered clear solution.

concentration :

100ug/200ul

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

other info2 :

Biological Activity: Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors

products description :

Description: Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 70kDa. The Progranulin is purified by standard chromatographic techniques. Introduction: A 88-kDa progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

ncbi gi num :

4504151

ncbi acc num :

NP_002078.1

ncbi gb acc num :

NM_002087.3

uniprot acc num :

P28799

ncbi mol weight :

44,132 Da

ncbi pathways :

Integrated Breast Cancer Pathway (219801)

ncbi summary :

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

uniprot summary :

GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion. Molecular Function: protein binding; growth factor activity; cytokine activity. Biological Process: blastocyst hatching; signal transduction; embryo implantation; positive regulation of epithelial cell proliferation. Disease: Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Ceroid Lipofuscinosis, Neuronal, 11

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

0.1 mg

price3 :

1220

more info or order :

MyBioSource product webpage