protein

Human Platelet Factor-4 (CXCL4)

MBS143174

0.02 mg

205 USD

Native Protein

Human Platelet Factor-4 (CXCL4)

Platelet Factor-4

PF 4 Human; Platelet Factor-4 Human (CXCL4); CXCL4; PF-4; PF4; Iroplact; Oncostatin-A; SCYB4; MGC138298

platelet factor 4; Platelet factor 4; platelet factor 4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; iroplact; oncostatin-A; platelet factor 4; C-X-C motif chemokine 4; Iroplact; Oncostatin-APlatelet factor 4, short form

PF 4

PF4; PF4; PF-4; CXCL4; SCYB4; CXCL4; SCYB4; PF-4

PLF4_HUMAN

Human Platelets

101

The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The CXCL4 protein was lyophilized in PBS buffer pH-7.4. Sterile Filtered white lyophilized powder.

Human CXCL4 although stable at 25 degree C 1 week, should be stored desiccated below -18 degree C. Please prevent freeze-thaw cycles.

Activity Control: Binding of HIT-antibodies.

Solubility: It is recommended to reconstitute the lyophilized CXCL4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

CHEMOKINES; Chemokines; Platelet Factor-4 (CXCL4)

Description: Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues. Introduction: Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

4505733

NP_002610.1

NM_002619.3

P02776

10,845 Da

CXCR3-mediated Signaling Events Pathway 138011!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Common Pathway 106060!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

0.02 mg

205 USD