catalog number :
MBS143130
products type :
Recombinant Protein
products full name :
Recombinant Human Anterior Gradient Protein 2 Homolog
products short name :
Anterior Gradient Protein 2 Homolog
products name syn :
AGR2 Human; Anterior Gradient Protein 2 Homolog Human Recombinant; Anterior gradient protein 2 homolog; Secreted cement gland protein XAG-2 homolog; AG-2; hAG-2; HPC8; AGR2; AG2; GOB-4; HAG-2; XAG-2
other names :
anterior gradient protein 2 homolog; Anterior gradient protein 2 homolog; anterior gradient protein 2 homolog; AG-2; HPC8; anterior gradient homolog 2; epididymis secretory protein Li 116; protein disulfide isomerase family A, member 17; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; anterior gradient 2; HPC8; Secreted cement gland protein XAG-2 homolog
products gene name :
AGR2
other gene names :
AGR2; AGR2; AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116; AG2; AG-2; hAG-2
uniprot entry name :
AGR2_HUMAN
sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRDT TVKPGAKKDT KDSRPKLPQT LSRGWGDQLI WTQTYEEALY KSKTSNKPLM IIHHLDECPH SQALKKVFAE NKEIQKLAEQ FVLLNLVYET TDKHLSPDGQ YVPRIMFVDP SLTVRADITG RYSNRLYAYE PADTALLLDN MKKALKLLKT EL.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
The protein contains 20mM Tris-HCl pH 8.0, 1mM DTT, 1mM EDTA and 10% Glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Anterior Gradient Protein
products description :
Description: Anterior Gradient Protein 2 Homolog Human Recombinant fused to His-tag on N-terminal produced in E Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (21-175) & having a molecular mass of 22 kDa. Introduction: AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor.
ncbi acc num :
NP_006399.1
ncbi gb acc num :
NM_006408.3
ncbi mol weight :
19,979 Da
uniprot summary :
AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family. Protein type: Secreted, signal peptide; Secreted; Oncoprotein. Chromosomal Location of Human Ortholog: 7p21.3. Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region. Molecular Function: protein binding