protein

Recombinant Human Synaptobrevin-1

MBS143127

0.02 mg

140 USD

Recombinant Protein

Recombinant Human Synaptobrevin-1

Synaptobrevin-1

VAMP1 Human; Synaptobrevin-1 Human Recombinant; Vesicle-associated membrane protein 1; SYB1; VAMP-1; Synaptobrevin-1; VAMP1; DKFZp686H12131

vesicle-associated membrane protein 1 isoform 4; Vesicle-associated membrane protein 1; vesicle-associated membrane protein 1; synaptobrevin 1; synaptobrevin-1; vesicle-associated membrane protein 1 (synaptobrevin 1); Synaptobrevin-1

VAMP1

VAMP1; VAMP1; SYB1; SPAX1; VAMP-1; SYB1; VAMP-1

VAMP1_HUMAN

E Coli

116

MGSSHHHHHH SSGLVPRGSH MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQVEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY W.

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein solution (1mg/ml) contains 1X PBS and 1mM EDTA. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Synaptobrevin

Description: VAMP1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 111 amino acids and having a molecular mass of 11.9 kDa. Introduction: Synaptobrevin 1(Vehicle-associated membrane, VAMP1) is one of the key proteins in the SNARE complex which is involved in regulated exocytosis. Synaptobrevin1 binds to t-SNAREs, syntaxin (STX) and SNAP25, after the fusion of synaptic vesicles to plasma membrane.

662033932

NP_001284367.1

NM_001297438.1

P23763

12,658 Da

Disease Pathway (530764); Neurotoxicity Of Clostridium Toxins Pathway (105734); SNARE Interactions In Vesicular Transport Pathway (83057); SNARE Interactions In Vesicular Transport Pathway (467); Toxicity Of Botulinum Toxin Type D (BoNT/D) Pathway (1127571); Toxicity Of Botulinum Toxin Type F (BoNT/F) Pathway (1127572); Toxicity Of Botulinum Toxin Type G (BoNT/G) Pathway (1127573); Uptake And Actions Of Bacterial Toxins Pathway (1127565)

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p. Cellular Component: SNARE complex; synaptic vesicle; mitochondrial outer membrane; neuron projection; cell surface; synaptic vesicle membrane; integral to plasma membrane; cell junction; cytosol. Molecular Function: SNAP receptor activity; SNARE binding; protein binding. Biological Process: vesicle fusion; exocytosis; pathogenesis. Disease: Spastic Ataxia 1, Autosomal Dominant

0.02 mg

140 USD

0.1 mg

205

1 mg

1030