Recombinant Human Parkinson Disease Protein 7 | MyBioSource MBS143125 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Parkinson Disease Protein 7

catalog :

MBS143125

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143125

products type :

Recombinant Protein

products full name :

Recombinant Human Parkinson Disease Protein 7

products short name :

Parkinson Disease Protein 7

products name syn :

PARK7 Human; Parkinson Disease Protein 7 Human Recombinant; PARK7; Parkinson disease protein 7; Oncogene DJ-1; Parkinson disease (autosomal recessive; early onset) 7

other names :

protein DJ-1; Protein DJ-1; protein DJ-1; Parkinson disease (autosomal recessive, early onset) 7; epididymis secretory sperm binding protein Li 67p; oncogene DJ1; parkinson protein 7; Oncogene DJ1; Parkinson disease protein 7

products gene name :

PARK7

other gene names :

PARK7; PARK7; DJ1; DJ-1; HEL-S-67p

uniprot entry name :

PARK7_HUMAN

host :

E Coli

sequence length :

189

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The protein solution (1mg/ml) contains 20mM Tris-HCl pH-8 and 20% glycerol. Sterile Filtered colorless solution.

concentration :

1mg/ml

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: PARK7 Human Recombinant fused to an N-terminal 36 aa His-Tag, produced in E Coli is a single, non-glycosylated polypeptide chain (aa 1-189) containing 225 amino acids and having a molecular mass of 24 kDa. Introduction: The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).

ncbi gi num :

183227678

ncbi acc num :

NP_001116849.1

ncbi gb acc num :

NM_001123377.1

uniprot acc num :

Q99497

ncbi mol weight :

19,891 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913); Androgen Receptor Signaling Pathway (198806); Parkinson's Disease Pathway (83098); Parkinsons Disease Pathway (705377); Synaptic Vesicle Pathway (672457)

ncbi summary :

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration. Protein type: Transcription regulation; Tumor suppressor; EC 3.4.-.-; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 1p36.23. Cellular Component: PML body; mitochondrion; mitochondrial matrix; axon; cytoplasm; plasma membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; chromatin; nucleus; cytosol; lipid raft. Molecular Function: identical protein binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; transcription coactivator activity; mercury ion binding; transcription factor binding; mRNA binding; peptidase activity; protein binding; enzyme binding; copper ion binding; peroxiredoxin activity; androgen receptor binding; cytokine binding; double-stranded DNA binding; glyoxalase III activity; superoxide dismutase copper chaperone activity; kinase binding; single-stranded DNA binding; receptor binding. Biological Process: negative regulation of protein export from nucleus; adult locomotory behavior; protein deglycosylation; membrane hyperpolarization; proteolysis; glycolate biosynthetic process; positive regulation of interleukin-8 production; negative regulation of protein amino acid phosphorylation; regulation of mitochondrial membrane potential; single fertilization; regulation of neuron apoptosis; enzyme active site formation via L-cysteine sulfinic acid; dopamine uptake; negative regulation of neuron apoptosis; negative regulation of protein binding; inflammatory response; mitochondrion organization and biogenesis; protein stabilization; activation of protein kinase B; regulation of TRAIL receptor biosynthetic process; detoxification of copper ion; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein sumoylation; positive regulation of peptidyl-serine phosphorylation; methylglyoxal catabolic process to D-lactate; positive regulation of protein kinase B signaling cascade; membrane depolarization; detoxification of mercury ion; regulation of inflammatory response; Ras protein signal transduction; negative regulation of ubiquitin-protein ligase activity; hydrogen peroxide metabolic process; negative regulation of protein kinase activity; autophagy; lactate biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; negative regulation of apoptosis. Disease: Parkinson Disease 7, Autosomal Recessive Early-onset

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2920

more info or order :

MyBioSource product webpage