protein

Recombinant Human Syntaxin-1A

MBS143124

1 mg

2665 USD

Recombinant Protein

Recombinant Human Syntaxin-1A

Syntaxin-1A

STX1A Human; Syntaxin-1A Human Recombinant; STX1; HPC-1; p35-1; Syntaxin-1A; Neuron-specific antigen HPC-1; STX-1A; STX1A

syntaxin-1A isoform 2; Syntaxin-1A; syntaxin-1A; neuron-specific antigen HPC-1; syntaxin 1A (brain); Neuron-specific antigen HPC-1

STX1A

STX1A; STX1A; STX1; HPC-1; P35-1; SYN1A; STX1

STX1A_HUMAN

E Coli

251

MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQ.

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein solution contains 20mM Tris-HCl pH7.5, 10% glycerol, and 1mM DTT. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Syntaxin

Description: Syntaxin-1A Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 226 amino acids (1-226) and having a molecular mass of 26.1 kDa.Recombinant Human STX1A contains N-terminal domain (Habc) and t_SNARE domain (H3 domain). Introduction: Syntaxin is membrane integrated Q-SNARE protein participating in exocytosis. Syntaxin is composed of an N-terminal regulatory domain (Habc), a SNARE domain (known as H3), and a single C-terminal transmembrane domain. The SNARE (H3) domain binds to both synaptobrevin and SNAP-25 forming the core SNARE complex. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces exocytosis.

259906442

NP_001159375.1

NM_001165903.1

Q16623

28,995 Da

Acetylcholine Neurotransmitter Release Cycle Pathway 106525!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!Disease Pathway 530764!!Dopamine Neurotransmitter Release Cycle Pathway 106523!!Effects Of Botulinum Toxin Pathway 138028!!GABA Synthesis, Release, Reuptake And Degradation Pathway 187174!!Glutamate Neurotransmitter Release Cycle Pathway 106522!!Insulin Processing Pathway 105903!!Insulin Secretion Pathway 777534

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

1 mg

2665 USD