protein

Human Apolipoprotein-H

MBS143103

0.1 mg

205 USD

Native Protein

Human Apolipoprotein-H

Apolipoprotein-H

APOH Human; Apolipoprotein-H Human; Beta-2-glycoprotein 1; Beta-2-glycoprotein I; Apolipoprotein H; Apo-H; B2GPI; Beta(2)GPI; Activated protein C-binding protein; APC inhibitor; Anticardiolipin cofactor; APOH; B2G1; BG; B2GP-1; B2 Glycoprotein-I

beta-2-glycoprotein 1; Beta-2-glycoprotein 1; beta-2-glycoprotein 1; APC inhibitor; B2GPI; activated protein C-binding protein; anticardiolipin cofactor; apo-H; beta(2)GPI; apolipoprotein H (beta-2-glycoprotein I); APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI

APOH

APOH; APOH; BG; B2G1; B2GP1; B2G1; Apo-H; B2GPI; Beta(2)GPI

APOH_HUMAN

Human Plasma

345

Greater than 96.0%.

Lyophilized from 0.02M NH4HCO3. Sterile Filtered White lyophilized (freeze-dried) powder.

Human APOH although stable at room temperature for 3 weeks, should be stored between 2-8 degree C.

Solubility: It is recommended to reconstitute the lyophilized APOHin phosphate buffer, pH >7.0 containing 0.15M NaCl. Human Virus Test: Starting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.

RECOMBINANT & NATURAL PROTEINS; Cytokines; Apolipoprotein

Description: Human APOH produced in Human Plasma having a molecular mass of 50kDa and pI of 5.6-6.4. It's a major phospholipid binding protein and an important component to measure in the assessment of anti-phospholipid syndrome. APOH is also more specific than anti-cardiolipin antibodies and its presence correlates better with thrombotic risk. Introduction: Apolipoprotein H (APOH) attaches to numerous kinds of negatively charged substances for instance heparin, phospholipids, and dextran sulfate. APOH prevents activation of the intrinsic blood coagulation cascade by attaching to phospholipids on the surface of damaged cells. APOH expressed by the liver and secreted in the plasma.

153266841

NP_000033.2

NM_000042.2

P02749

38,298 Da

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Protein type: Lipid-binding; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface. Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding. Biological Process: negative regulation of myeloid cell apoptosis; negative regulation of angiogenesis; positive regulation of blood coagulation; negative regulation of fibrinolysis; triacylglycerol metabolic process; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis

0.1 mg

205 USD

1 mg

790

5 mg

3205