Human Alpha-2 Macroglobulin Protein | MyBioSource MBS143102 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Alpha-2 Macroglobulin Protein

catalog :

MBS143102

quantity :

0.2 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143102

products type :

Native Protein

products full name :

Human Alpha-2 Macroglobulin Protein

products short name :

Alpha-2 Macroglobulin

products name syn :

A2M Human; Macroglobulin Alpha-2 Human; Alpha-2-macroglobulin; Alpha-2-M; A2M; CPAMD5; FWP007; S863-7; alpha 2M; DKFZp779B086

other names :

alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-M; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

products gene name :

A2M

other gene names :

A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; CPAMD5; Alpha-2-M

uniprot entry name :

A2MG_HUMAN

host :

Human Plasma

sequence length :

1474

purity :

Greater than 96.0%.

form :

Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8 degree C. Do not freeze!

other info2 :

Solubility: It is recommended to reconstitute the lyophilized A2M in sterile 18M Omega -cm H2O. Human Virus Test: Serum from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HBSAG.

products categories :

RECOMBINANT & NATURAL PROTEINS; Natural Proteins

products description :

Description: Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa. Introduction: Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it's composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the œbait region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.

ncbi gi num :

66932947

ncbi acc num :

NP_000005.2

ncbi gb acc num :

NM_000014.4

uniprot acc num :

P01023

ncbi mol weight :

163,291 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway (106059)

ncbi summary :

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

uniprot summary :

A2M: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Protein type: Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: extracellular region; cytosol. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding. Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway. Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency

size1 :

0.2 mg

price1 :

140 USD

size2 :

1 mg

price2 :

205

size3 :

10 mg

price3 :

1030

more info or order :

MyBioSource product webpage